200863-97-4Relevant articles and documents
PENTACYCLIC TRITERPENOIDS FROM PRUNELLA VULGARIS
Kojima, Hisashi,Tominaga, Hideo,Sato, Shigeki,Ogura, Haruo
, p. 1107 - 1112 (1987)
Three new pentacyclic triterpenes together with several known triterpenes have been isolated as their methyl esters from the roots of Prunella vulgaris. - Key Word Index: Prunella vulgaris; Labiatae; triterpenoids; 2α,3α-dihydroxyursa-12,20(30)-dien-28-oic acid; 2α,3α,24-trihydroxyursa-12,20(30)-dien-28-oic acid; 2α,3α,24-trihydroxyoleana-11,13(18)-dien-28-oic acid.
Synthesis and biological evaluation of novel asiatic acid derivatives with anticancer activity
Gon?alves, Bruno M. F.,Salvador, Jorge A. R.,Marín, Silvia,Cascante, Marta
, p. 3967 - 3985 (2016/01/25)
Asiatic acid (AA) is a pentacyclic triterpenoid with recognized anticancer properties. Structural modification of AA may afford derivatives with improved anticancer potency. Hence, in this paper, a series of new lactol and A-nor AA derivatives were prepared, and their antiproliferative activities against several human cancer cell lines and a non-tumoral fibroblast cell line (BJ) were tested. Among all the derivatives tested, compound 24 proved to be the most active compound, with IC50 values ranging from 0.11 μM to 0.65 μM for cancer cell lines. The molecular mechanisms underlying its antiproliferative activity were further investigated using the HeLa cell line. Our results showed that treatment of HeLa cells with compound 24 led to cell-cycle arrest at the G0/G1 phase, which was associated with an upregulation of p21cip1/waf1 and p27kip1 and a downregulation of cyclin D3. Moreover, compound 24 induced apoptotic HeLa cell death via the activation of caspase-9, caspase-8, and caspase-3. The downregulation of the Bcl-2 and Bid proteins and the upregulation of the Bax protein suggest that the mitochondrial pathway is activated during the apoptotic process.
Triterpenes from Prunus africana bark
Fourneau,Hocquemiller,Cave
, p. 1387 - 1389 (2007/10/03)
A chloroformic extract of barks of Prunus africana was found to contain triterpenic acids including derivatives of ursolic and oleanolic acids. Among them 24-O-trans-ferulyl-2α,3α-dihydroxy-urs-12-en-28-oic acid, an original compound, was isolated. Their structure was established by chemical and spectral analysis.
Triterpenoids from Eucalyptus Perriniana Cultured Cells
Furuya, Tsutomu,Orihara, Yutaka,Hayashi, Chisato
, p. 715 - 720 (2007/10/02)
Eight triterpenes were isolated from the methanol extracts of Eucalyptus perriniana cultured cells as their methyl esters.The structures were elucidated by spectral data to be oleanolic acid, ursolic acid, maslinic acid, 2α-hydroxyursolic acid, hederagenin, 23-hydroxyursolic acid, arjunolic acid and asiatic acid.Key word Index - Eucalyptus perriniana; Myrtaceae; plant cell culture; triterpene; arjunolic acid; asiatic acid; hederagenin; 23-hydroxyursolic acid; maslinic acid; 2α-hydroxyursolic acid; oleanolic acid; ursolic acid.
TERPENOIDS OF RHODODENDRON JAPONICUM
Sakakibara, Jinsaku,Kaiya, Toyo
, p. 2547 - 2552 (2007/10/02)
From Rhododendron japonicum were isolated two diterpene glucosides, pieroside B and grayanoside B, and two new triterpenes, 2α,3α,24-trihydroxyurs-12-en-28-oic acid and 2α,3α,19,24-tetrahydroxyurs-12-en-28-oic acid, whose structures were established by chemical and spectroscopic means.Key Word Index - Rhododendron japonica; Ericaceae; diterpene glucoside; triterpene; pieroside B; grayanoside B; asiatic acid; 2α,3α,24-trihydroxyurs-12-en-28-oic acid; 2α,3α,19,24-tetrahydroxyurs-12-en-28-oic acid.
