200878-50-8

Basic information

• Product Name: 2-bromo-7-methoxy-9H-carbazole
• Synonyms: 2-bromo-7-methoxy-9H-carbazole;2-Bromo-7-methoxy-9H-carbazole
• CAS NO: 200878-50-8
• Molecular Formula: C₁₃H₁₀BrNO
• Molecular Weight: 276.1286
• Mol File: 200878-50-8.mol

Chemical Properties

• Melting Point: 284 °C
• Boiling Point: 442.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.567±0.06 g/cm3(Predicted)
• PKA: 16.03±0.30(Predicted)
• CAS DataBase Reference: 2-bromo-7-methoxy-9H-carbazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-7-methoxy-9H-carbazole(200878-50-8)
• EPA Substance Registry System: 2-bromo-7-methoxy-9H-carbazole(200878-50-8)

Safety Data

• Hazardous Substances Data: 200878-50-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-7-methoxy-9H-carbazole is used as an intermediate in the preparation of dicationic carbazoles, which are effective antibacterial agents against Pneumocystis carinii pneumonia in rats. These dicationic carbazoles also possess the ability to inhibit topoisomerase II, an enzyme that plays a crucial role in DNA replication and transcription. By inhibiting topoisomerase II, these compounds can potentially disrupt the growth and proliferation of bacteria, making them a promising candidate for the development of new antibacterial drugs.

Upstream product

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Downstream Products

• 200878-51-9 2-bromo-7-methoxy-9-methylcarbazole 

Relevant articles and documents

Linear-type carbazoledioxazine-based organic semiconductors: The effect of backbone planarity on the molecular orientation and charge transport properties

We report the synthesis of a linear-type dibromocarbazoledioxazine (CZ) derivative as a new precursor for semiconducting polymers. The chemical structures of the CZ unit and its polymers with thiophene or thienothiophene spacers (namely, PCZT and PCZTT) were fully characterized. PCZT and PCZTT possessed similar medium optical band gap (Eoptg) and electrochemical band gap (Ecvg) of around 1.70 eV estimated from the onset absorption and electrochemical redox potentials of the thin films, respectively. Computational density functional theory (DFT) calculations suggested that the backbone of the PCZT might be highly twisted, while that of PCZTT could be very planar. The effect of different backbone geometries on the charge-transport properties was studied by using thin film transistors (TFTs). The TFT device based on PCZTT showed a four times higher hole mobility as compared to that based on PCZT. The superior TFT performances of PCZTT were reasonably attributed to its edge-on backbone packing orientations toward the Si substrate revealed by the grazing-incidence wide-angle X-ray scattering (GIWAXS), which was favorable for in-plane charge transport in the TFT devices.

COMPOUND FOR PHOTOELECTRIC CONVERTING DEVICE

A photoelectric converting device and an image sensing device having the same are provided. When a compound having a specific structure is used for the photoelectric converting device, a function as photoelectric converting device can be developed, and a lower dark current is present in the device. Even when heating is applied to the device, increase of the dark current can be reduced. A photoelectric converting device has a photoelectric converting film including a photoelectric converting layer and an electron blocking layer between a transparent conductive film and a conductive film, wherein the electron blocking layer includes a compound having 3 or more ring structures and substituent groups substituted amino group.

Vanadium-catalyzed regioselective oxidative coupling of 2-hydroxycarbazoles

The first regioselective oxidative coupling of 2-hydroxycarbazoles is described. With a vanadium catalyst and oxygen as the terminal oxidant, dimers with an ortho-orthoa?2 coupling pattern were obtained with high selectivity. Further oxidation led to orthoa?2-orthoa?2 coupling to generate a tetramer, which provided insight that the atropisomerization barriers of the unsymmetrical biaryl bonds are much lower than expected.

Anti-Pneumocystis carinii pneumonia activity of dicationic carbazoles

A series of 2,7- and 3,6-bis cationic carbazoles was synthesized and evaluated for activity against a rat model of Pneumocystis carinii pneumonia (PCP). The compounds were also tested for inhibition of topoisomerase II and binding to DNA. Several of the compounds proved to be more potent and less toxic than a standard anti-PCP drug (pentamidine). While no quantitative correlation was seen between anti-PCP activity, topoisomerase inhibition and DNA binding, a minimal level of DNA binding was found to be necessary for antimicrobial activity.