200932-31-6Relevant articles and documents
TOPICAL FORMULATIONS
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Page/Page column 89, (2008/12/05)
There is provided topical pharmaceutical compositions comprising compounds of formula (I) wherein R1, R2, R3 and X have meanings given in the description. These compositions can be used to treat microbial infections and to
USE OF PYRROLOQUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS
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Page/Page column 87, (2008/06/13)
There is provided the use of compounds of formula (I), wherein R1 R2 R3 and X have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided
Potential antineoplastics. Synthesis and cytotoxicity of certain 4- chloro-3-(2-chloroethyl)-2-methylquinolines and related derivatives
Badawey,Kappe
, p. 815 - 822 (2007/10/03)
In an extension of our work in the held of nitrogen heterocycles with potential cytotoxic activity, the synthesis of some substituted 4-chloro-3- (2-chloroethyl)-2-methylquinolines (10-13) from their parent 3-[l- (phenylamino)ethylidene]-dihydro-2(3H)-furanones (6-9) is reported. The conversion of 10-13 to some thieno-, furo- and pyrrolo[3,2-c]quinolines (14- 27, 31-33) is also described. The compounds were evaluated for their toxicity in brine shrimp (Artemia salina), and their cytotoxicity against some clinically isolated human tumors in vitro. Several compounds exhibited good toxic activity against Artemia salina, while the furanone (6, NSC 680781) displayed good antineoplastic activity and high selectivity against some cell lines from leukemia, lung cancer, colon and melanoma panels. This compound has been selected by the NCI for further testing in a new in vivo anticancer hollow fiber assay.