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2-acetylbutyrolactone CAS 517-23-7 C6H8O3
Cas No: 517-23-7
USD $ 20.0-20.0 / Metric Ton 20 Metric Ton 20 Metric Ton/Day Changsha Easchem Co.,Limited Contact Supplier
High quality 2-Acetylbutyrolactone
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No Data 1 Kilogram 1000 Metric Ton/Year Hefei TNJ chemical industry co.,ltd Contact Supplier
a-acetylene-r-butyrolactone(ABL)
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No Data No Data 3300 Metric Ton/Day SHANGHAI HUIAN CHEMICAL CO.LTD Contact Supplier
High quality 2-Acetylbutyrolactone CAS NO.517-23-7
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Top purity 2-Acetylbutyrolactone with high quality and best price cas:517-23-7
Cas No: 517-23-7
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USD $ 1.0-1.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Scale Chemical Corporation Contact Supplier
alpha-Acetyl-gaMMa-butyrolactone
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No Data 1 Kilogram 1 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
2-Acetylbutyrolactone /CAS 517-23-7
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α-Acetyl-τ-butyrolactone
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517-23-7 Usage

Reference

  1. Asghari, S.; Mohammadi, L., Reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates in the presence of 2-acetylbutyrolactone. Synthesis of functionalized alpha-methylene-gamma-butyrolactones. Tetrahedron Lett. 2006, 47, 4297-4299.
  2. Rao, V. R.; Kumar, P. V., Facile one-pot synthesis of 3-{2- 5-hydroxy-4-(2-hydroxy-ethyl)-3-methyl-pyrazol-1-yl -thiazol-4-yl} -chromen-2-ones via a three-component reaction. Synth. Commun. 2006, 36, 2157-2161.
  3. Horne, D. A.; Fugmann, B.; Yakushijin, K.; Buchi, G., A SYNTHESIS OF PILOCARPINE. J. Org. Chem. 1993, 58, 62-64.
  4. Sabry, S. M., Application of 2-acetylbutyrolactone to spectrofluorinietry: Fluorescence properties of Schiff bases derived from 2-acetylbutyrolactone and spectrofluorimetric determination of primary amine-containing compounds. J. Pharm. Biomed. Anal. 2006, 40, 1057-1067.

Uses

In synthesis of 3,4-disubstituted pyridines; of 5-(b-hydroxethyl)-4-methylthiazole.

Description

It is an important intermediate involved in the synthesis of chemical and pharmaceutical products such as vitamin B, 3,4-substituted pyridine, 5-(2-Hydroxyethyl)-4-methylthiazole. In presence of 2-acetylbutyrolactone, reaction of tert-butyl isocyanide with dialkyl acetylenedicarboxylates leads to the formation of dialkyl (E)-2-{(tert-butylamino)[2-oxo-4,5-dihydro-3(2H)-furanylidene]methyl}-2-butenedioates.1 Moreover, reaction of 2-acetylbutyrolactone with thiosemicarbazide and 3-(2-bromo-acetyl)-chromen-2-one in anhydrous ethanol produced 3-{2-[5-hydroxyl-4-(2-hydroxyl-ethyl)-3-methyl-pyrazol-1-yl]-thiazol-4-yl}-chromen-2-one in good yields.2 In addition, 2-acetylbutyrolactone can also function as the raw material for synthesizing pilocarpine that is a leading therapeutic agent for the treatment of narrow and wide angle glaucoma.3 Besides, this chemical can also act as a fluorogenic reagent in the quantitative spectrofluorometric determination of primary amines, which has been demonstrated to be equally accurate and precise as the officially or other reported methods.4

Uses

An intermediate in the synthesis of 2,4-disubstituted pyridines. A fluorogenic reagent for the spectrofluorimetric determination of primary amines.

Chemical Properties

Colorless to light yellow liqui
InChI:InChI=1/C6H8O3/c1-4(7)5-2-3-9-6(5)8/h5H,2-3H2,1H3/t5-/m0/s1

517-23-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (A13409)  α-Acetylbutyrolactone  ≥99% 517-23-7 A13409-500G 1,123.20CNY Detail
Aldrich (A13409)  α-Acetylbutyrolactone  ≥99% 517-23-7 A13409-100G 452.79CNY Detail
Alfa Aesar (B22967)  alpha-Acetyl-gamma-butyrolactone, 98+%    517-23-7 500g 606.0CNY Detail
Alfa Aesar (B22967)  alpha-Acetyl-gamma-butyrolactone, 98+%    517-23-7 100g 217.0CNY Detail

517-23-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name α-Acetylbutyrolactone

1.2 Other means of identification

Product number -
Other names α-Acetyl-γ-butyrolactone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:517-23-7 SDS

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