- Preparation method of 2-thioxo-2,3-dihydroquinazoline-4(1H)-one compound
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The invention discloses a preparation method of a 2-thioxo-2,3-dihydroquinazoline-4(1H)-one compound. The preparation method of the compound of formula I includes the following steps: a compound of formula II and a compound of formula III are subjected to a condensation reaction in an organic solvent under the action of an organic base to obtain the compound of the formula I, wherein the reactiontemperature is 70-155 DEG C, X1, X2, X3 and X4 are independently hydrogen or halogen, and R is hydrogen or one of alkyl groups of C1-C4. The preparation method provided by the invention is mild in conditions, environment-friendly, low in cost, high in yield, simple and efficient, and is suitable for industrial production. The formula of the reaction is shown in the description.
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Paragraph 0041-0043; 0091-0093; 0097; 0098
(2018/12/05)
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- Preparation of fungicidal quinazolinones and useful intermediates
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PCT No. PCT/US97/10254 Sec. 371 Date Dec. 9, 1998 Sec. 102(e) Date Dec. 9, 1998 PCT Filed Jun. 12, 1997 PCT Pub. No. WO97/48684 PCT Pub. Date Dec. 24, 1997This invention provides advantageous processes for preparing quinazolinones of Formula I wherein: R1 is C1-C10 alkyl; C3-C10 alkenyl; C3-C10 cycloalkyl; C3-C10 halocycloalkyl; C4-C10 cycloalkylalkyl; C4-C10 halocycloalkylalkyl; or C3-C10 alkynyl; R2 is C1-C10 alkyl; C3-C10 alkenyl; C3-C10 cycloalkyl; C3-C10 halocycloalkyl; C4-C10 cycloalkylalkyl; C4-C10 halocycloalkylalkyl; C4-C10 cycloalkyl; C4-C10 halocycloalkyl; or C3-C10 alkynyl; and R3 and R4 are each independently hydrogen or halogen; from compounds containing the moiety IIg This invention further provides certain compounds of Formula II, IIIa, or IVa where R7 is C2-C6 alkyl.
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