200938-58-5

Usage

Uses

Used in Pharmaceutical Research:
6-iodo-3-propyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one is used as a research compound for exploring its potential biological activities and therapeutic applications. Its unique chemical structure may offer insights into the development of new drugs and treatment strategies.
Used in Drug Development:
In the pharmaceutical industry, 6-iodo-3-propyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one is utilized as a lead compound for the design and synthesis of novel therapeutic agents. Its structural features can be further modified to enhance its pharmacological properties and target specific biological pathways.
Further investigation into the properties and potential uses of 6-iodo-3-propyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one could be beneficial for the scientific community, as it may contribute to the advancement of medicine and healthcare.

Upstream product

• 628-30-8 n-Propyl isothiocyanate 
• 5326-47-6 2-amino-5-iodobenzoic acid 
• 927-67-3 propylthiourea 
• 541-41-3 chloroformic acid ethyl ester 

Relevant academic research and scientific papers

Preparation method of 2-thioxo-2,3-dihydroquinazoline-4(1H)-one compound

The invention discloses a preparation method of a 2-thioxo-2,3-dihydroquinazoline-4(1H)-one compound. The preparation method of the compound of formula I includes the following steps: a compound of formula II and a compound of formula III are subjected to a condensation reaction in an organic solvent under the action of an organic base to obtain the compound of the formula I, wherein the reactiontemperature is 70-155 DEG C, X1, X2, X3 and X4 are independently hydrogen or halogen, and R is hydrogen or one of alkyl groups of C1-C4. The preparation method provided by the invention is mild in conditions, environment-friendly, low in cost, high in yield, simple and efficient, and is suitable for industrial production. The formula of the reaction is shown in the description.

Preparation of fungicidal quinazolinones and useful intermediates

PCT No. PCT/US97/10254 Sec. 371 Date Dec. 9, 1998 Sec. 102(e) Date Dec. 9, 1998 PCT Filed Jun. 12, 1997 PCT Pub. No. WO97/48684 PCT Pub. Date Dec. 24, 1997This invention provides advantageous processes for preparing quinazolinones of Formula I wherein: R1 is C1-C10 alkyl; C3-C10 alkenyl; C3-C10 cycloalkyl; C3-C10 halocycloalkyl; C4-C10 cycloalkylalkyl; C4-C10 halocycloalkylalkyl; or C3-C10 alkynyl; R2 is C1-C10 alkyl; C3-C10 alkenyl; C3-C10 cycloalkyl; C3-C10 halocycloalkyl; C4-C10 cycloalkylalkyl; C4-C10 halocycloalkylalkyl; C4-C10 cycloalkyl; C4-C10 halocycloalkyl; or C3-C10 alkynyl; and R3 and R4 are each independently hydrogen or halogen; from compounds containing the moiety IIg This invention further provides certain compounds of Formula II, IIIa, or IVa where R7 is C2-C6 alkyl.