201609-28-1

Basic information

• Product Name: 1-BOC-4-(2-METHOXYPHENYL)-4-HYDROXYPIPERIDINE
• Synonyms: 1-BOC-4-(2-METHOXYPHENYL)-4-HYDROXYPIPERIDINE;tert-butyl 4-hydroxy-4-(2-methoxyphenyl)piperidine-1-carboxylate
• CAS NO: 201609-28-1
• Molecular Formula: C₁₇H₂₅NO₄
• Molecular Weight: 307.388
• Mol File: 201609-28-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BOC-4-(2-METHOXYPHENYL)-4-HYDROXYPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-(2-METHOXYPHENYL)-4-HYDROXYPIPERIDINE(201609-28-1)
• EPA Substance Registry System: 1-BOC-4-(2-METHOXYPHENYL)-4-HYDROXYPIPERIDINE(201609-28-1)

Safety Data

• Hazardous Substances Data: 201609-28-1(Hazardous Substances Data)

Usage

Type of Compound

Organic chemical compound

Application

Used in the field of organic chemistry and pharmaceutical synthesis

BOC-protected derivative

4-(2-methoxyphenyl)-4-hydroxypiperidine

BOC group

tert-butoxycarbonyl protective group

Function of BOC group

Protects the amine group during chemical reactions

2-Methoxyphenyl group

Phenyl ring with a methoxy substituent at the 2-position

Presence of hydroxy group

Adds value in the synthesis of organic compounds

Presence of piperidine ring

Contributes to potential pharmacological properties

Intermediate role

Used in the synthesis of various organic compounds with potential applications in the pharmaceutical industry

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 335343-05-0 5,5-dimethyl-2-(2-methoxyphenyl)-[1,3,2]dioxaborinane 
• 16750-63-3 2-methoxyphenylmagnesium bromide 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 578-57-4 2-bromoanisole 

Downstream Products

• 58333-75-8 4-(2-methoxyphenyl)piperidine 
• 1552303-62-4 C₂₇H₃₆BrNO₃ 
• 201609-29-2 1-t-Butoxycarbonyl-4-(2-methoxyphenyl)piperidine 
• 194669-41-5 1-t-Butoxycarbonyl-4-(2-methoxyphenyl)-1,2,3,6-tetrahydropyridine 
• 154422-95-4 1,2,3,6-tetrahydro-4-(2-methoxyphenyl)pyridine 

Relevant articles and documents

Bulky N-Heterocyclic-Carbene-Coordinated Palladium Catalysts for 1,2-Addition of Arylboron Compounds to Carbonyl Compounds

The synthesis of primary, secondary, and tertiary alcohols by the 1,2-addition of arylboronic acids or boronates to carbonyl compounds, including unactivated ketones, using novel bulky yet flexible N-heterocyclic carbene (NHC)-coordinated 2,6-di(pentan-3-yl)aniline (IPent)-based cyclometallated palladium complexes (CYPs) as catalysts is reported. The PhS-IPent-CYP-catalyzed reactions are efficient at low catalyst loadings (0.02–0.3 mol% Pd), and the exceptional catalytic activity for 1,2-addition is attributed to the steric bulk of the NHC ligand. These reactions can yield a wide range of functionalized benzylic alcohols that are difficult to synthesize by classical protocols using highly active organomagnesium or lithium reagents.

Successful reduction of off-target hERG toxicity by structural modification of a T-type calcium channel blocker

To obtain an optimized T-type calcium channel blocker with reduced off-target hERG toxicity, we modified the structure of the original compound by introducing a zwitterion and reducing the basicity of the nitrogen. Among the structurally modified compound

Ni-catalysed, domino synthesis of tertiary alcohols from secondary alcohols

The use of in situ generated (NHC)-Ni catalytic species (NHC = N-heterocyclic carbene) allows for the synthesis, in short reaction times, of a variety of tertiary alcohols from secondary alcohols through a domino oxidation-addition protocol.

Tetrahydrobenzindole compounds

A compound of formula (I) for use in the treatment or prevention of mental diseases A is N, CH, C having a double bond or CR5; each of B and Z is independently N, CH or CR1, with the proviso that A is N when B and/or Z is N; R1, R2, R3, R4and R5and n are as defined in the specification.