cas 201856-57-7, (3R,4S)-tert-Butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate | Articles data ｜lookchem

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201856-57-7

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A [...] he [...] synthesis process
A [...] he [...] synthesis process, in order to (3 R, 4 S) - 3 - hydroxy - 4 - phenyl - 2 - azetidinone as the starting material, adopts the one-pot synthesis, its first with vinyl ether condensation, with the BOC - anhydride is condensed directly [...] h
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Paragraph 0013

(2019/04/06)

Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) STR1 with β-lac
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(2008/06/13)

Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) STR1 with β-lac
-
(2008/06/13)

A highly efficient route to taxotere by the β-lactam synthon method
Taxotere, a highly promising anticancer drug, is synthesized through an efficient coupling of 7,10-diTroc-10-deacetylbaccatin III with enantiomerically pure (3R,4S)-1-tBOC-3-EEO- 4-phenylazetidin-2-one which is obtained via chiral ester enolate - imine cyclocondensation.
Ojima, Iwao,Sun, Chung Ming,Zucco, Martine,Park, Young Boon,Duclos, Olivier,Kuduk, Scott
p. 4149 - 4152
(2007/10/02)

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Chemical Properties

Boiling Point: 459.592 °C at 760 mmHg
Flash Point:231.753 °C
Density: 1.161 g/cm³
Storage Temp.:2-8°C
Vapor Pressure: 1.25E-08mmHg at 25°C
Refractive Index: 1.532
PKA: -4.97±0.60(Predicted)
PSA: 65.07000
LogP: 3.21060

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