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201856-48-6

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201856-48-6 Usage

Description

(3R,4S)-3-(1-Ethoxyethoxy)-4-phenyl-2-azetidinone is a chiral chemical compound with the molecular formula C14H21NO3. It is a white to off-white crystalline solid that serves as a pharmaceutical intermediate in the synthesis of various drugs. (3R,4S)-3-(1-Ethoxyethoxy)-4-phenyl-2-azetidinone features two stereocenters and is known for its potential pharmacological properties, such as inhibiting certain enzymes and receptors in the body. The ethoxyethoxy and phenyl groups attached to the azetidinone ring are crucial for its biological activity and overall pharmacokinetics, making it a versatile chemical with promising applications in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
(3R,4S)-3-(1-Ethoxyethoxy)-4-phenyl-2-azetidinone is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure and chirality allow for the development of enantiomer-specific medications, which can have different therapeutic effects and reduce potential side effects.
Used in Drug Development:
(3R,4S)-3-(1-Ethoxyethoxy)-4-phenyl-2-azetidinone is used as a starting material in drug development, enabling the creation of novel compounds with potential therapeutic applications. Its ability to inhibit certain enzymes and receptors makes it a valuable candidate for the treatment of various diseases and conditions.
Used in Medicinal Chemistry Research:
(3R,4S)-3-(1-Ethoxyethoxy)-4-phenyl-2-azetidinone is used as a research tool in medicinal chemistry to study the structure-activity relationships of compounds and to optimize their pharmacological properties. Its unique features, such as the ethoxyethoxy and phenyl groups, provide insights into the design of more effective and selective drugs.
Used in Drug Synthesis:
(3R,4S)-3-(1-Ethoxyethoxy)-4-phenyl-2-azetidinone is used in the synthesis of complex drug molecules, where its chiral centers and functional groups can be further modified to achieve the desired biological activity and pharmacokinetic properties. (3R,4S)-3-(1-Ethoxyethoxy)-4-phenyl-2-azetidinone serves as a versatile building block for the development of innovative therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 201856-48-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,1,8,5 and 6 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 201856-48:
(8*2)+(7*0)+(6*1)+(5*8)+(4*5)+(3*6)+(2*4)+(1*8)=116
116 % 10 = 6
So 201856-48-6 is a valid CAS Registry Number.

201856-48-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(1-ethoxyethoxy)-4-phenylazetidin-2-one

1.2 Other means of identification

Product number -
Other names (3R,4S)-3-(1-Ethoxyethoxy)-4-phenyl-2-azetidinone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:201856-48-6 SDS

201856-48-6Relevant articles and documents

A [...] he [...] synthesis process

-

Paragraph 0013, (2019/04/06)

A [...] he [...] synthesis process, in order to (3 R, 4 S) - 3 - hydroxy - 4 - phenyl - 2 - azetidinone as the starting material, adopts the one-pot synthesis, its first with vinyl ether condensation, with the BOC - anhydride is condensed directly [...] h

Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment

-

, (2008/06/13)

The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) STR1 with β-lac

New and efficient approaches to the semisynthesis of taxol and its C-13 side chain analogs by means of β-lactam synthon method

Ojima, Iwao,Habus, Ivan,Zhao, Mangzhu,Zucco, Martine,Park, Young Hoon,Sun, Chung Ming,Brigaud, Thierry

, p. 6985 - 7012 (2007/10/02)

Highly efficient chiral ester enolate-imine condensation giving 3-hydroxy-4-aryl-β-lactams with excellent enantiomeric purity is successfully applied to the asymmetric synthesis of the enantiomerically pure taxol C-13 side chain, N-benzoyl-(2R,3S)-3-phenyl-isoserine and its analogs. (3R,4S)-N-benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone readily derived from the 3-hydroxy-4-phenyl-β-lactam is coupled with protected baccatin IIIs, followed by deprotection to give optically pure taxol and 10-deacetyl-7,10-bis(Troc)-taxol in good yields. Fully assigned 1H, 13C, and 2D (COSY and HETCOR) NMR spectra of taxol thus synthesized are shown and discussed.

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