- A PROCESS FOR SYNTHESIS OF LARGE PARTICLE SIZE STATIN COMPOUNDS.
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This invention discloses a process for synthesis of with large size statin compounds comprising adding solution of desired statin compound either crystalline or amorphous form, optionally obtained from, their intermediates by known methods, in organic solvent to anti-solvent, under stirring, optionally the solvent was being evaporated, isolating the title compound by centrifugation followed by drying under vacuum. Specifically the process was directed to the synthesis of Atorvastatin calcium and Fluvastatin Sodium.
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Page/Page column 22
(2008/06/13)
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- Method of separating optically active dihydroxy-heptenoic acid esters
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An optically active dihydroxyheptenoic acid ester having an aromatic group is separated from a solution containing a mixture of optical isomers of digydroxyheptenoic acid ester by liquid chromatography with a packing material constituted of a carrier and
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Page/Page column 7
(2008/06/13)
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- PROCESS FOR PREPARATING ENANTIOMERICALLY PURE FLUVASTATIN SODIUM AND A NOVEL POLYMORPHIC FORM THEREOF
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The present invention provides processes for preparing enantiomerically pure fluvastatin sodium. The present invention also provides pharmaceutical compositions comprising the enantiomerically pure fluvastatin sodium for antagonizing HMG-CoA. In addition
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Page/Page column 21-22
(2008/06/13)
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- PROCESS AND INTERMEDIATES FOR THE SELECTIVE SYNTHESIS OF FLUVASTATIN
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The invention relates to process for the selective preparation of 3-hydroxy-6-dialkoxyphosphoryl-5-oxo-hexanoic acid esters, comprising a first step, in which a methylphosphonic acid dialkylester is treated with a base, and a second step, in which the pro
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Page/Page column 10
(2010/10/20)
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- A Novel Method for the In Situ Generation of Alkoxydialkylboranes and Their Use in the Selective Preparation of 1,3-Syn Diols
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An in situ method for generating Et2BOCH3 from triethylborane and methanol without using any other catalysts is described.Using the Et2BOCH3 thus generated as a chelating agent, syn 1,3-diols are prepared in > 98 percent stereochemical purity by reducing β-hydroxy-ketones with sodium borohydride
- Chen, Kau-Ming,Gunderson, Karl G.,Hardtmann, Goetz E.,Prasad, Kapa,Repic, Oljan,Shapiro, Michael J.
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p. 1923 - 1926
(2007/10/02)
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- 1,3-SYN DIASTEREOSELECTIVE REDUCTION OF β-HYDROXYKETONES UTILIZING ALKOXYDIALKYLBORANES
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Sodium borohydride reduction of β-hydroxyketones in presence of alkoxydialkylboranes 1-7 as complexing agents, produced 1,3-syn diols in at least 98:2 ratio.As illustrated with examples 8-17 this method is quite general and superior to those described in
- Chen, Kau-Ming,Hardtmann, Goetz E.,Prasad, Kapa,Repic, Oljan,Shapiro, Michael J.
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p. 155 - 158
(2007/10/02)
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