20296-09-7

Basic information

• Product Name: 8-Aminopurine
• Synonyms: 8-AMINOPURINE;1H-Purin-8-amine (9CI);8-Amino-7H-purine;1H-Purine-8-amine;8-Amino-9H-purine;9H-Purin-8-amine;7H-purin-8-aMine
• CAS NO: 20296-09-7
• Molecular Formula: C₅H₅N₅
• Molecular Weight: 135.13
• Product Categories: PYRIMIDINE;Purines
• Mol File: 20296-09-7.mol

Chemical Properties

• Boiling Point: 423.073 °C at 760 mmHg
• Flash Point: 239.253 °C
• Appearance: /
• Density: 1.612 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.837
• CAS DataBase Reference: 8-Aminopurine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Aminopurine(20296-09-7)
• EPA Substance Registry System: 8-Aminopurine(20296-09-7)

Safety Data

• Hazardous Substances Data: 20296-09-7(Hazardous Substances Data)

Usage

Uses

Used in Biochemical and Pharmaceutical Research:
8-Aminopurine is used as a research tool for studying the structure and function of nucleic acids, as well as the mechanisms of enzyme activity and inhibition. Its ability to inhibit adenosine deaminase makes it a valuable compound in understanding enzyme kinetics and the development of potential therapeutic agents.
Used in Antiviral and Antitumor Applications:
8-Aminopurine is used as a potential antiviral and antitumor agent due to its ability to inhibit adenosine deaminase, an enzyme involved in the metabolism of adenosine. This inhibition can lead to increased levels of adenosine, which has antiviral and antitumor effects.
Used in the Production of Nucleotide Analogs:
8-Aminopurine is used as a precursor in the synthesis of nucleotide analogs, which are important in the development of antiviral and anticancer drugs. These analogs can be incorporated into DNA or RNA, interfering with the replication and transcription processes of viruses and cancer cells.
Used in Molecular Biology:
8-Aminopurine is used as a component in various DNA and RNA synthesis reactions, allowing researchers to study the mechanisms of nucleic acid synthesis and the interactions between nucleic acids and proteins. It also plays a role in the study of protein synthesis and cell signaling pathways, providing insights into cellular processes and potential targets for therapeutic intervention.

InChI:InChI=1/C5H5N5/c6-5-9-3-1-7-2-8-4(3)10-5/h1-2H,(H3,6,7,8,9,10)

Upstream product

• 33426-53-8 8-methylthiopurine 
• 583-40-4 9H-purine-8(7H)-thione 

Downstream Products

• 1234620-30-4 ethyl (rac)-6-(4-cyanophenyl)-8-methyl-9-[3-(trifluoromethyl)phenyl]-6,9-dihydropyrimido[2,1-f]purine-7-carboxylate 
• 1234620-32-6 Ethyl (rac)-9-(4-cyanophenyl)-7-methyl-6-[3-(trifluoromethyl)phenyl]-6,9-dihydropyrimido[1,2-e]-purin-8-carboxylate 
• 1234620-78-0 (rac)-Ethyl 6-(4-cyanophenyl)-8-methyl-6,9-dihydropyrimido[2,1-f]purine-7-carboxylate 
• 1234620-79-1 (rac)-ethyl 9-(4-cyanophenyl)-7-methyl-6,9-dihydropyrimido[1,2-e]purine-8-carboxylate 

Relevant articles and documents

4'-substituted nucleosides

Nucleosides compounds of Formula I: STR1 wherein B is a purine or a pyrimidine; X and X' are H; Y is H; Y' is OH, F or H; or Y' and X' together makes a bond; Z is STR2 where n is zero, one, two or three; or Y' and Z together form a cyclic phosphate ester; Z' is --CN, --CH3, CH2 N3 or --CH2 J, where J is a halogen atom; or Z' and Y' together are --CH2 O--; and pharmaceutically acceptable esters, ethers, amides, N-acyl moieties and salts thereof.