583-40-4 Usage
Description
8-Mercaptopurine, also known as 6-MP, is a purine analogue that functions as a chemotherapy drug. It is primarily used in the treatment of various cancers and autoimmune diseases. 8-Mercaptopurine interferes with DNA synthesis, thereby inhibiting the growth and multiplication of cancer cells. The drug is typically administered orally and is metabolized in the body to produce active derivatives that disrupt nucleic acid biosynthesis, making it effective against both dividing and non-dividing cancer cells. Despite its therapeutic benefits, 8-Mercaptopurine can cause side effects such as bone marrow suppression, liver toxicity, and an increased risk of infections.
Uses
Used in Oncology:
8-Mercaptopurine is used as a chemotherapeutic agent for the treatment of various types of cancers. It is particularly effective in targeting the DNA synthesis of cancer cells, thereby obstructing their growth and proliferation. The drug's mechanism of action involves the interference with nucleic acid biosynthesis, making it a potent weapon against both dividing and non-dividing cancer cells.
Used in Autoimmune Disease Treatment:
8-Mercaptopurine is also used as an immunosuppressive drug in the management of autoimmune diseases. Its ability to interfere with DNA synthesis and nucleic acid biosynthesis helps in reducing the activity of the immune system, thus alleviating the symptoms of autoimmune conditions.
Used in Drug Metabolism Studies:
The metabolism of 8-Mercaptopurine in the body provides valuable insights into drug metabolism and pharmacokinetics. Understanding how the body processes this compound can aid in the development of more effective and safer chemotherapy drugs and other therapeutic agents.
Used in Pharmaceutical Research:
8-Mercaptopurine's structure, based on the purine found in DNA and RNA, makes it a significant compound in pharmaceutical research. Its properties and effects on cellular processes are studied to develop new drugs and therapies for various diseases, including cancer and autoimmune disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 583-40-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,8 and 3 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 583-40:
(5*5)+(4*8)+(3*3)+(2*4)+(1*0)=74
74 % 10 = 4
So 583-40-4 is a valid CAS Registry Number.
InChI:InChI=1/C5H4N4S/c10-5-8-3-1-6-2-7-4(3)9-5/h1-2H,(H2,6,7,8,9,10)
583-40-4Relevant articles and documents
HINDERED DISULFIDE DRUG CONJUGATES
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Page/Page column 127; 135, (2017/05/02)
The invention relates generally to disulfide drug conjugates wherein a linker comprising a sulfur-bearing carbon atom substituted with at least one hydrocarbyl or substituted hydrocarbyl is conjugated by a disulfide bond to a cysteine sulfur atom of a targeting carrier, and wherein the linker is further conjugated to a drug moiety. The invention further relates to activated linker-drug conjugates suitable for conjugation to a targeting carrier by a disulfide bond. The invention further relates to methods for preparing hindered disulfide drug conjugates.
NOVEL VIRAL REPLICATION INHIBITOR
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Page/Page column 19; 41, (2008/06/13)
The present invention relates to a pharmaceutical composition for the treatment or prevention of viral infections comprising as an active principle at least one benzimidazole conjugates derivative havin the general formula I. The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula and their use as a medicine or to treat or prevent viral infections.
