203062-02-6Relevant articles and documents
Synthesis of3H-, 13C3-, and 14C-labeled Sch 727965
Lavey, C. Flader,Hesk,Koharski,Truong,McNamara
, p. 196 - 201 (2011)
The preparation of [3H]Sch 727965 from unlabeled compound and tritiated water was base catalyzed. Diethyl [13C3]malonate was used to prepare [13C3]Sch 727965 in five steps in 21.8% overall yield. In a similar manner, [14C]Sch 727965 was prepared in five steps from diethyl [2-14C]malonate in 11.1% radiochemical yield. Copyright
CDK inhibitor based on organic arsine as well as preparation method and application of CDK inhibitor
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Paragraph 0379-0381; 0385-0387, (2021/03/31)
The invention provides a CDK inhibitor based on organic arsine as well as a preparation method and application of the CDK inhibitor. Specifically, the invention providese compounds of Formula I, or stereoisomers or tautomers thereof, or pharmaceutically acceptable salts, hydrates or solvates thereof; and the invention also discloses a preparation method and application thereof. Definitions of allgroups in the formula are shown in the specification.
Synthesis of 3-amino-4-substituted pyrazole derivatives
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Page/Page column 7, (2010/11/25)
This application discloses a novel process to synthesize 3-amino-4-substituted pyrazole derivatives, which may be used, for example, as intermediates to prepare compounds having, for example, pharmaceutical utility.
Pyrazolotriazines as kinase inhibitors
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Page/Page column 18, (2008/06/13)
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]triazine compounds as inhibitors of kinases such as, for example, cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing
Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
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, (2008/06/13)
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS
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Page 30, (2008/06/13)
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
Studies on nonpeptide angiotensin II receptor antagonists. I. Synthesis and biological evaluation of pyrazolo [1,5-b][1,2,4]triazole derivatives with alkyl substituents
Okazaki, Toshio,Suga, Akira,Watanabe, Toshihiro,Kikuchi, Kazumi,Kurihara, Hiroyuki,Shibasaki, Masayuki,Fujimori, Akira,Inagaki, Osamu,Yanagisawa, Isao
, p. 69 - 78 (2007/10/03)
Alkyl-substituted pyrazolo[1,5-b][1,2,4]triazole derivatives were synthesized and evaluated for activity as angiotensin II receptor antagonists. Molecules with the (methylbiphenylyl)tetrazole moiety at N-5 were the preferred compounds. Ethyl substitutions
Pyrazolotriazole derivatives
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, (2008/06/13)
This invention relates to a pyrazolotriazole derivative represented by the general formula: STR1 wherein each symbol means as follows; R1, R3 and R4 : one of them represents hydrogen, tetrazolylated biphenylmethyl or lower
