The present invention relates to acrylonitrile compounds of formula (1): [wherein, R is a C1-C6alkyl, a C3-C7cycloalkyl optionally substituted by a C1-C4alkyl, a naphthyl, etc., R1/su
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Page/Page column 50
(2010/01/31)
Reaction of 2-phenyl substituted 1,2,3-triazol 1-oxides with acylating agents. Preparation of hydroxy- halogen- hydroxymethyl- and chloromethyltriazoles
2-Phenyltriazol 1-oxides react with acetyl chloride producing acetoxy- and chloro-substituted triazoles.The substituents enter the 5 and the 4-position.When these are not accessible the substituents go to lateral positions and to the phenyl group producing acetoxymethyltriazoles and 2-halogenophenyl triazoles.Acetic anhydride reacts reluctantly while trifluoroacetic anhydride is more reactive producing trifluoroacetoxytriazoles.The reactions provide effective routes to hydroxy- and hydroxymethyltriazoles.Several mechanisms among which a cyclic one are operating.
Begtrup, Mikael
p. 717 - 728
(2007/10/03)
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