13322-19-5

Basic information

• Product Name: (5-METHYL-2-PHENYL-2H-1,2,3-TRIAZOL-4-YL)METHANOL
• Synonyms: (5-METHYL-2-PHENYL-2H-1,2,3-TRIAZOL-4-YL)METHANOL
• CAS NO: 13322-19-5
• Molecular Formula: C₁₀H₁₁N₃O
• Molecular Weight: 189.21
• Mol File: 13322-19-5.mol

Chemical Properties

• Melting Point: 75 °C
• Boiling Point: 392°Cat760mmHg
• Flash Point: 190.9°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 7.58E-07mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: 2-8°C
• PKA: 12.99±0.10(Predicted)
• CAS DataBase Reference: (5-METHYL-2-PHENYL-2H-1,2,3-TRIAZOL-4-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (5-METHYL-2-PHENYL-2H-1,2,3-TRIAZOL-4-YL)METHANOL(13322-19-5)
• EPA Substance Registry System: (5-METHYL-2-PHENYL-2H-1,2,3-TRIAZOL-4-YL)METHANOL(13322-19-5)

Safety Data

• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 13322-19-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(5-METHYL-2-PHENYL-2H-1,2,3-TRIAZOL-4-YL)METHANOL is used as a building block for the synthesis of various pharmaceutical compounds, owing to its versatile hydroxyl group that allows for the creation of a wide range of drug molecules.
Used in Medicinal Chemistry Research:
(5-METHYL-2-PHENYL-2H-1,2,3-TRIAZOL-4-YL)METHANOL is utilized as a key component in the development of new drugs, given its potential antimicrobial, antifungal, and anticancer properties, which are valuable for research and development in the pharmaceutical sector.
Used in Drug Development:
(5-METHYL-2-PHENYL-2H-1,2,3-TRIAZOL-4-YL)METHANOL is employed as a precursor in the formulation of new therapeutic agents, capitalizing on the pharmacological activities associated with the triazole ring system to address various medical conditions.

InChI:InChI=1/C10H11N3O/c1-8-10(7-14)12-13(11-8)9-5-3-2-4-6-9/h2-6,14H,7H2,1H3

Upstream product

• 15256-65-2 4,5-dimethyl-2-phenyl-1,2,3-triazole-1-oxide 
• 22300-56-7 5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxylic acid 
• 75-36-5 acetyl chloride 
• 127-08-2 potassium acetate 
• 145324-77-2 4-iodomethyl-5-methyl-2-phenyl-1,2,3-triazole 

Downstream Products

• 13322-02-6 4-(bromomethyl)-5-methyl-2-phenyl-2H-1,2,3-triazole 
• 203444-17-1 4-chloromethyl-5-methyl-2-phenyl-2H-[1,2,3]triazole 

Relevant articles and documents

PYRAZOLE DERIVATIVES

A compound represented by the general formula (I), which is useful as a peroxisome proliferator-activated receptor α/γ agonist, a salt of the compound, and a solvate of either. (In the formula, X, Y, and Z each represents nitrogen or carbon; m is an integ

Acrylonitrile compounds

The present invention relates to acrylonitrile compounds of formula (1): [wherein, R is a C1-C6alkyl, a C3-C7cycloalkyl optionally substituted by a C1-C4alkyl, a naphthyl, etc., R1/su

Reaction of 2-phenyl substituted 1,2,3-triazol 1-oxides with acylating agents. Preparation of hydroxy- halogen- hydroxymethyl- and chloromethyltriazoles

2-Phenyltriazol 1-oxides react with acetyl chloride producing acetoxy- and chloro-substituted triazoles.The substituents enter the 5 and the 4-position.When these are not accessible the substituents go to lateral positions and to the phenyl group producing acetoxymethyltriazoles and 2-halogenophenyl triazoles.Acetic anhydride reacts reluctantly while trifluoroacetic anhydride is more reactive producing trifluoroacetoxytriazoles.The reactions provide effective routes to hydroxy- and hydroxymethyltriazoles.Several mechanisms among which a cyclic one are operating.

Activation of Exocyclic α-Positions of Azole N-Oxides by O-Silylation

Exocyclic α-positions at immonium ring carbon atoms of pyrazole and 1,2,3-triazole 1-oxides are selectively attacked in a one-pot sequence comprising silylation with iodotrimethylsilane, deprotonation with 1,2,2,6,6-pentamethylpiperidine and allylic substitution of the trimethylsilyloxy group with the iodide ions liberated by the silylation.In this way 3- and 5-iodomethylpyrazoles as well as 4-iodomethyl-1,2,3-triazoles are obtained in good yields.These may be useful for the preparation of heteroarylmethyl derivatives since the iodine atom can be displaced by even weak nucleophiles such as acetate ions.The side chain iodination is complementary to O-alkylation of the N-oxides followed by nucleophilic attack which preferentially takes place at ring carbon atoms.