203503-03-1

Basic information

• Product Name: (3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine
• Synonyms: (3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine;1-Piperidinecarboxylic acid, 4-aMino-3-hydroxy-, 1,1-diMethylethyl ester;tert-butyl 4-AMino-3-hydroxy-1-piperidinecarboxylate;1,1-Dimethylethyl 4-amino-3-hydroxy-1-piperidinecarboxylate;tert-Butyl 4-amino-3-hydroxypiperidine-1-carboxylate;N1-BOC-4-aMino-3-hydroxypiperidine
• CAS NO: 203503-03-1
• Molecular Formula: C₁₀H₂₀N₂O₃
• Molecular Weight: 216.2774
• Mol File: 203503-03-1.mol

Chemical Properties

• Boiling Point: 326.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.142±0.06 g/cm3(Predicted)
• PKA: 14.37±0.40(Predicted)
• CAS DataBase Reference: (3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine(203503-03-1)
• EPA Substance Registry System: (3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine(203503-03-1)

Safety Data

• Hazardous Substances Data: 203503-03-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine is used as a key building block for the synthesis of various pharmaceuticals and bioactive molecules. Its unique structure and the presence of a BOC-protected amino group make it a valuable intermediate in the development of new drugs with specific therapeutic properties.
Used in Organic Chemistry:
(3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine is used as a versatile chemical intermediate in organic chemistry for the synthesis of complex organic compounds. The BOC group can be easily removed under mild acidic conditions, enabling further functionalization of the molecule for specific applications in organic synthesis.
Used in Drug Development:
(3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine is used as a starting material in the development of new drugs and materials. Its wide-ranging potential in medicinal chemistry allows researchers to explore its use in the creation of innovative therapeutic agents with improved efficacy and selectivity.
Used in Bioactive Molecule Synthesis:
(3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine is used as a crucial component in the synthesis of bioactive molecules with potential applications in various fields, such as pharmaceuticals, agrochemicals, and materials science. Its unique structure and functional groups contribute to the development of molecules with specific biological activities.

Upstream product

• 161157-50-2 tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate 
• 85838-94-4 N-Boc-1,2,3,6-tetrahydropyridine 
• 1427170-50-0 C₁₁H₂₀N₂O₄ 
• 71233-28-8 3-hydroxypiperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 
• 71233-25-5 ethyl 1-tert-butoxycarbonyl-3-oxopiperidine-4-carboxylate 
• 203503-02-0 tert-butyl (3RS,4RS)-4-azido-3-hydroxy-piperidine-1-carboxylate 

Downstream Products

• 1565846-67-4 C₁₈H₂₆BrN₃O₃ 
• 1565853-00-0 C₁₆H₃₀N₂O₃ 
• 652170-11-1 4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-tert-butoxycarbonyl-3-piperidinol 
• 652171-10-3 4-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-tert-butoxycarbonyl-3-piperidinol 
• 203501-32-0 {(S)-1-[4-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-hydroxy-piperidine-1-carbonyl]-3-methyl-butyl}-methyl-carbamic acid benzyl ester 
• 203501-38-6 [(S)-1-(1-Acetyl-3-hydroxy-piperidin-4-ylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester 
• 203501-30-8 ((S)-1-{1-[(4R,S)-((S)-2-benzyloxycarbonylamino-4-methylpentanoylamino)-(3R,S)-hydroxypiperidin-1-yl]methanoyl}-3-methylbutyl)carbamic acid benzyl ester 
• 203503-04-2 (4R,S)-((S)-2-benzyloxycarbonylamino-4-methylpentanoylamino)-(3R,S)-hydroxypiperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF

The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

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