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(3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine is a BOC-protected amino alcohol with a molecular formula C11H22N2O3. It features a piperidine ring with an amino group and a hydroxyl group at the 4th and 3rd positions, respectively, in the R configuration. (3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine is widely used in organic and medicinal chemistry as a building block for the synthesis of various pharmaceuticals and bioactive molecules. The BOC group can be easily removed under mild acidic conditions, allowing for further functionalization of the molecule for specific applications. As a versatile and important chemical intermediate, (3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine has wide-ranging potential in the development of new drugs and materials.

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  • 203503-03-1 Structure
  • Basic information

    1. Product Name: (3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine
    2. Synonyms: (3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine;1-Piperidinecarboxylic acid, 4-aMino-3-hydroxy-, 1,1-diMethylethyl ester;tert-butyl 4-AMino-3-hydroxy-1-piperidinecarboxylate;1,1-Dimethylethyl 4-amino-3-hydroxy-1-piperidinecarboxylate;tert-Butyl 4-amino-3-hydroxypiperidine-1-carboxylate;N1-BOC-4-aMino-3-hydroxypiperidine
    3. CAS NO:203503-03-1
    4. Molecular Formula: C10H20N2O3
    5. Molecular Weight: 216.2774
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 203503-03-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 326.1±42.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.142±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 14.37±0.40(Predicted)
    10. CAS DataBase Reference: (3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine(CAS DataBase Reference)
    11. NIST Chemistry Reference: (3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine(203503-03-1)
    12. EPA Substance Registry System: (3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine(203503-03-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 203503-03-1(Hazardous Substances Data)

203503-03-1 Usage

Uses

Used in Pharmaceutical Industry:
(3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine is used as a key building block for the synthesis of various pharmaceuticals and bioactive molecules. Its unique structure and the presence of a BOC-protected amino group make it a valuable intermediate in the development of new drugs with specific therapeutic properties.
Used in Organic Chemistry:
(3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine is used as a versatile chemical intermediate in organic chemistry for the synthesis of complex organic compounds. The BOC group can be easily removed under mild acidic conditions, enabling further functionalization of the molecule for specific applications in organic synthesis.
Used in Drug Development:
(3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine is used as a starting material in the development of new drugs and materials. Its wide-ranging potential in medicinal chemistry allows researchers to explore its use in the creation of innovative therapeutic agents with improved efficacy and selectivity.
Used in Bioactive Molecule Synthesis:
(3R,4R)-N1-BOC-4-amino-3-hydroxypiperidine is used as a crucial component in the synthesis of bioactive molecules with potential applications in various fields, such as pharmaceuticals, agrochemicals, and materials science. Its unique structure and functional groups contribute to the development of molecules with specific biological activities.

Check Digit Verification of cas no

The CAS Registry Mumber 203503-03-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,3,5,0 and 3 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 203503-03:
(8*2)+(7*0)+(6*3)+(5*5)+(4*0)+(3*3)+(2*0)+(1*3)=71
71 % 10 = 1
So 203503-03-1 is a valid CAS Registry Number.

203503-03-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 4-amino-3-hydroxypiperidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names tert-butyl (3R*,4R*)-4-amino-3-hydroxy-piperidine-1-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:203503-03-1 SDS

203503-03-1Relevant articles and documents

TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF

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Paragraph 1092; 1094, (2017/01/23)

The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

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Page/Page column 36, (2015/07/07)

The present invention provides compounds of Formula (I) (Formula (I)) including pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

Synthesis and in vitro antibacterial activity of quinolone/naphthyridone derivatives containing 3-alkoxyimino-4-(methyl)aminopiperidine scaffolds

Lv, Kai,Wu, Jinwei,Wang, Jian,Liu, Mingliang,Wei, Zengquan,Cao, Jue,Sun, Yexin,Guo, Huiyuan

, p. 1754 - 1759 (2013/04/10)

We report herein the synthesis of a series of 7-[3-alkoxyimino-4-(methyl) aminopiperidin-1-yl]quinolone/naphthyridone derivatives. In vitro antibacterial activity of these derivatives was evaluated against representative strains, and compared with ciprofl

Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole

Ashton, Wallace T.,Sisco, Rosemary M.,Dong, Hong,Lyons, Kathryn A.,He, Huaibing,Doss, George A.,Leiting, Barbara,Patel, Reshma A.,Wu, Joseph K.,Marsilio, Frank,Thornberry, Nancy A.,Weber, Ann E.

, p. 2253 - 2258 (2007/10/03)

A series of β-aminoacylpiperidines bearing various fused five-membered heterocyclic rings was synthesized as dipeptidyl peptidase IV inhibitors. Potent and relatively selective inhibition could be obtained, depending on choice of heterocycle, regioisomerism, and substitution. In particular, one analog (74, DPP-IV IC50 = 26 nM) exhibited good oral bioavailability and acceptable half-life in the rat, albeit with rather high clearance.

1-PHENYLPIPERIDIN-3-ONE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

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Page 23, (2010/02/06)

The present invention provides 1-phenylpiperidin-3-one derivatives and pharmaceutically acceptable saltsthereof, having cysteine protease inhibitory activity, pharmaceutical compositions containing the sameas an active ingredient, and processes for the preparation thereof.

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