203503-03-1Relevant articles and documents
TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF
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Paragraph 1092; 1094, (2017/01/23)
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.
INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
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Page/Page column 36, (2015/07/07)
The present invention provides compounds of Formula (I) (Formula (I)) including pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Synthesis and in vitro antibacterial activity of quinolone/naphthyridone derivatives containing 3-alkoxyimino-4-(methyl)aminopiperidine scaffolds
Lv, Kai,Wu, Jinwei,Wang, Jian,Liu, Mingliang,Wei, Zengquan,Cao, Jue,Sun, Yexin,Guo, Huiyuan
, p. 1754 - 1759 (2013/04/10)
We report herein the synthesis of a series of 7-[3-alkoxyimino-4-(methyl) aminopiperidin-1-yl]quinolone/naphthyridone derivatives. In vitro antibacterial activity of these derivatives was evaluated against representative strains, and compared with ciprofl
Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole
Ashton, Wallace T.,Sisco, Rosemary M.,Dong, Hong,Lyons, Kathryn A.,He, Huaibing,Doss, George A.,Leiting, Barbara,Patel, Reshma A.,Wu, Joseph K.,Marsilio, Frank,Thornberry, Nancy A.,Weber, Ann E.
, p. 2253 - 2258 (2007/10/03)
A series of β-aminoacylpiperidines bearing various fused five-membered heterocyclic rings was synthesized as dipeptidyl peptidase IV inhibitors. Potent and relatively selective inhibition could be obtained, depending on choice of heterocycle, regioisomerism, and substitution. In particular, one analog (74, DPP-IV IC50 = 26 nM) exhibited good oral bioavailability and acceptable half-life in the rat, albeit with rather high clearance.
1-PHENYLPIPERIDIN-3-ONE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
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Page 23, (2010/02/06)
The present invention provides 1-phenylpiperidin-3-one derivatives and pharmaceutically acceptable saltsthereof, having cysteine protease inhibitory activity, pharmaceutical compositions containing the sameas an active ingredient, and processes for the preparation thereof.