203663-06-3Relevant articles and documents
Benzopiperidine derivatives
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, (2008/06/13)
Benzopiperidine derivatives represented by formula (I), salts thereof or hydrates thereof, processes for producing the same and drugs comprising the same: wherein the variables are as described in the specification. These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and rejection reaction accompanying organ transplantation.
Inhibitors of adhesion molecules expression; The synthesis and pharmacological properties of 10H-pyrazino[2,3-b][1,4]benzothiazine derivatives
Kaneko, Toshihiko,Clark, Richard S. J.,Ohi, Norihito,Kawahara, Tetsuya,Akamatsu, Hiroshi,Ozaki, Fumihiro,Kamada, Atsushi,Okano, Kazuo,Yokohama, Hiromitsu,Muramoto, Kenzo,Ohkuro, Masayoshi,Takenaka, Osamu,Kobayashi, Seiichi
, p. 922 - 929 (2007/10/03)
During a search for novel, orally-active inhibitors of upregulation of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1), we found a new series of 10H-pyrazino[2,3-b][1,4]benzothiazine derivatives to be potent ICAM-1 inhibitors. Of the