- Fluorine-Containing Organozinc Reagents. Part I. A Simple Synthesis of 2,2-Dichloro-3,3,3-trifluoropropanol
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The title compound 1, which can be regarded as synthetic equivalent of substituted 1,1,1-trifluoroacetone 2, is prepared by Zn-induced reductive addition of 1,1,1-trichloro-2,2,2-trifluoroethane (3) to formaldehyde (4).A brief survey of the scope of this C-C-bond formation leading to a variety of new CF3-containing synthetic building blocks is also given.
- Lang, Robert Werner
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p. 881 - 886
(2007/10/02)
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