204394-52-5Relevant articles and documents
Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1
Zhang, Pengtao,Yang, Xinye,Zhang, Feiran,Gabelli, Sandra B.,Wang, Renxiao,Zhang, Yihua,Bhat, Shridhar,Chen, Xiaochun,Furlani, Manuel,Amzel, L. Mario,Liu, Jun O.,Ma, Dawei
, p. 2600 - 2617 (2013/06/27)
Cellular protein synthesis is initiated with methionine in eukaryotes with few exceptions. Methionine aminopeptidases (MetAPs) which catalyze the process of N-terminal methionine excision are essential for all organisms. In mammals, type 2 MetAP (MetAP2)