51285-26-8Relevant articles and documents
A Mitochondria-Targeted Photosensitizer Showing Improved Photodynamic Therapy Effects Under Hypoxia
Lv, Wen,Zhang, Zhang,Zhang, Kenneth Yin,Yang, Huiran,Liu, Shujuan,Xu, Aqiang,Guo, Song,Zhao, Qiang,Huang, Wei
, p. 9947 - 9951 (2016)
Organelle-targeted photosensitizers have been reported to be effective photodynamic therapy (PDT) agents. In this work, we designed and synthesized two iridium(III) complexes that specifically stain the mitochondria and lysosomes of living cells, respectively. Both complexes exhibited long-lived phosphorescence, which is sensitive to oxygen quenching. The photocytotoxicity of the complexes was evaluated under normoxic and hypoxic conditions. The results showed that HeLa cells treated with the mitochondria-targeted complex maintained a slower respiration rate, leading to a higher intracellular oxygen level under hypoxia. As a result, this complex exhibited an improved PDT effect compared to the lysosome-targeted complex, especially under hypoxia conditions, suggestive of a higher practicable potential of mitochondria-targeted PDT agents in cancer therapy.
A gas-phase study on the cyclometallation of a series of Cp*Ir(III) complexes bearing bidentate pyrimidine ligands
Becker, Yanik,Huber, Maximilian,Becker, Sabine,Sun, Yu,Niedner-Schatteburg, Gereon,Thiel, Werner R.
, (2021/09/20)
A concerted approach of synthesis and gas phase experiments characterizes the relative cyclometallation barriers of a series of cationic η5-Cp* iridium(III) compounds. The common feature of the investigated compounds is a bidentate N,N’-donor ligand possessing a pyridine site functionalized with a 5-butylpyrimidin-2-yl ring in the 2-position. In addition, the pyridine ring was functionalized with electron-donating or -withdrawing groups. The compounds were characterized by means of NMR and IR spectroscopy and elemental analysis. For the measurements of the relative barriers of the cyclometallation, collision-induced dissociation (CID) experiments were carried out, which revealed a clear dependence of the relative barriers from the nature and the position of the substituents at the pyridine ring could be worked out.
The phosphorescence of the response characteristic of a complex, and its preparation method and application
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Paragraph 0032-0035, (2017/04/29)
The invention relates to a phosphorescent iridium complex with stimuli responsibility. The phosphorescent iridium complex is composed of a cyclometalated ligand, a metal center and an assistant ligand containing an active function group, and has the structure general formula shown in the specification. The compound disclosed by the invention is capable of causing variation of phosphorescence emission wavelength under stimulation of an acidic or basic reagent; also under electricity stimulation, the compound is capable of causing variation of emission wavelength and also is capable of causing variation of emission lifetime; and based on the electricity stimulation response characteristics and by means of time resolution technology, the phosphorescent iridium complex is applicable to construct memory devices for information recording, encryption and decryption. The phosphorescent iridium complex disclosed by the invention has important application prospect on aspects of information recording, information encryption and the like.
