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204582-53-6

8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE is a chemical compound derived from 8-Oxo-2'-deoxyguanosine (O850250), which serves as a marker for DNA damage linked to mutagenesis and carcinogenesis. 8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE has the potential to induce differentiation in certain cell types, such as Friend murine erythroleukemia cells in vitro.

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  • 8-Bromo-5'-O-(dimethyoxytrityl)-N2-(dimethyl-aminomethylidene)-2'-deoxyguanosine

    Cas No: 204582-53-6

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  • 204582-53-6 Structure

  • Basic information

    1. Product Name: 8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE
    2. Synonyms: 8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE;8-BROMO-5'-O-(DMT)-N2-(DMF)-2'-DEOXYGUANOSINE;8-Bromo-5'-O-(dimethyoxytrityl)-N2-(dimethyl-aminomethylidene)-2'-deoxyguanosine
    3. CAS NO:204582-53-6
    4. Molecular Formula: C34H35BrN6O6
    5. Molecular Weight: 703.58
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 204582-53-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE(204582-53-6)
    11. EPA Substance Registry System: 8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE(204582-53-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 204582-53-6(Hazardous Substances Data)

204582-53-6 Usage

Uses

Used in Research Applications:
8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE is used as a research tool for studying DNA damage, mutagenesis, and carcinogenesis due to its role as a marker compound indicative of these processes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE is used as a potential therapeutic agent for inducing differentiation in certain types of cancer cells, such as Friend murine erythroleukemia cells.
Used in Diagnostic Applications:
8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE can be utilized in the development of diagnostic tools and tests to detect and monitor DNA damage associated with mutagenesis and carcinogenesis.

Check Digit Verification of cas no

The CAS Registry Mumber 204582-53-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,4,5,8 and 2 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 204582-53:
(8*2)+(7*0)+(6*4)+(5*5)+(4*8)+(3*2)+(2*5)+(1*3)=116
116 % 10 = 6
So 204582-53-6 is a valid CAS Registry Number.

204582-53-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:204582-53-6 SDS

204582-53-6Relevant articles and documents

Synthesis and properties of oligonucleotides containing 8-bromo-2′-deoxyguanosine

Fabrega, Carme,Macias, Maria J.,Eritja, Ramon

, p. 251 - 260 (2001)

The preparation of oligonucleotides containing 8-bromo-2′-deoxyguanosine is described. Substitution of G by 8-bromoguanine on an alternating CG decamer stabilizes the Z-form in such a way that the B-form was not observed. Melting temperatures showed that duplexes in which 8-bromo-2′-deoxyguanosine paired with natural bases were much less stable.

DNA duplexes stabilized by modified monomer residues: Synthesis and stability

Graham, Duncan,Parkinson, John A.,Brown, Tom

, p. 1131 - 1138 (2007/10/03)

The synthesis of a series of 2′-deoxyuridine analogues modified at the 5-position and a series of 2′-deoxypurines modified at the 8-position is described. Ultraviolet melting studies have been used to assess the stability of DNA duplexes 12- and 8-residue

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