717876-75-0

Basic information

• Product Name: 8-BROMO-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE
• Synonyms: 8-BROMO-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE
• CAS NO: 717876-75-0
• Molecular Formula: C₁₃H₁₇BrN₆O₄
• Molecular Weight: 401.22
• Mol File: 717876-75-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-BROMO-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BROMO-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE(717876-75-0)
• EPA Substance Registry System: 8-BROMO-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE(717876-75-0)

Safety Data

• Hazardous Substances Data: 717876-75-0(Hazardous Substances Data)

Usage

Uses

Used in Research Applications:
8-BROMO-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE is used as a research compound for studying its unique solvatochromic fluorescent properties. This characteristic makes it a valuable tool in various scientific investigations, particularly in the fields of biochemistry and molecular biology.
Used in Analytical Chemistry:
In analytical chemistry, 8-BROMO-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE is employed as a fluorescent probe to detect and analyze various chemical and biological substances. Its solvatochromic properties enable selective detection and quantification of target molecules in complex samples.
Used in Pharmaceutical Development:
8-BROMO-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE is utilized in the development of new pharmaceuticals, particularly those targeting nucleic acid-based therapies. Its unique properties can potentially be harnessed to improve drug delivery and targeting, leading to more effective treatments for various diseases.
Used in Material Science:
In material science, 8-BROMO-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE is explored for its potential applications in the creation of advanced materials with unique optical and electronic properties. Its solvatochromic fluorescence can be exploited to develop new types of sensors, displays, and other technological devices.

Upstream product

• 13389-03-2 8-bromo-2'-deoxyguanosine 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 204582-53-6 5'-O-(dimethoxytrityl)-N²-(N,N-dimethylaminomethyliden)-8-bromo-2'-deoxyguanosine 
• 1277165-62-4 C₅₃H₆₁N₈O₈P 
• 1277165-59-9 C₄₄H₄₄N₆O₇ 
• 1277165-50-0 (E)-8-(4-acetylstyryl)-2'-deoxyguanosine 
• 1277165-47-5 C₂₃H₂₆N₆O₅ 
• 204582-55-8 N⁽²⁾-dimethylaminomethylene-8-(prop-1-ynyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine 

Relevant articles and documents

Fluorescence switching of photochromic vinylpyrene-substituted 2′-deoxyguanosine

We synthesized C8-vinylpyrene-substituted 2′-deoxyguanosine VPyG and studied the photoregulated reversible E-Z isomerization. When E-isomer was irradiated with visible light (>420 nm), E- to Z-isomerization took place very rapidly, while upon i

Design and synthesis of highly solvatochromic fluorescent 2′-deoxyguanosine and 2′-deoxyadenosine analogs

We synthesized various substituted 8-styryl-2′-deoxyguanosine and 8-styryl-2′-deoxyadenosine derivatives. Among them only acetyl substituted 8-styryl-2′-deoxyguanosine analog 5b showed a remarkable solvatochromicity (Δλmaxem=91nm),th

Synthesis of novel push-pull-type solvatochromic 2′-deoxyguanosine derivatives with longer wavelength emission

We synthesized novel push-pull-type fluorescent guanosine derivatives, CNG and AcG containing 1,6- and 2,7-disubstituted pyrene chromophores. 1,6-Disubstituted pyrene derivatives, 1,6-CNG (3b) and 1,6-AcG (3c),

Synthesis and properties of oligonucleotides containing 8-bromo-2′-deoxyguanosine

The preparation of oligonucleotides containing 8-bromo-2′-deoxyguanosine is described. Substitution of G by 8-bromoguanine on an alternating CG decamer stabilizes the Z-form in such a way that the B-form was not observed. Melting temperatures showed that duplexes in which 8-bromo-2′-deoxyguanosine paired with natural bases were much less stable.

DNA duplexes stabilized by modified monomer residues: Synthesis and stability

The synthesis of a series of 2′-deoxyuridine analogues modified at the 5-position and a series of 2′-deoxypurines modified at the 8-position is described. Ultraviolet melting studies have been used to assess the stability of DNA duplexes 12- and 8-residue