20474-55-9Relevant articles and documents
MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS
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, (2012/07/14)
The present invention relates to novel fluorinated macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
Facile synthesis of 2-(2-ethoxy-1,2-dioxoethyl)azoles
Geraschenko, Oleksandr V.,Khodakovskiy, Pavel V.,Shishkin, Oleg V.,Mykhailiuk, Pavel K.,Zaporozhets, Olga A.,Tolmachev, Andrey A.
experimental part, p. 1633 - 1637 (2011/06/25)
C-Acylation of N-substituted imidazoles with ethyl oxalyl chloride in the presence of N,N-diisopropylethylamine as a base afforded 2-(2-ethoxy-1,2- dioxoethyl)imidazoles in 83-95% yield. Application of this synthetic protocol to thiazoles and triazoles le