20478-70-0

Basic information

• Product Name: DECANOICACIDHYDRAZIDE
• Synonyms: DECANOICACIDHYDRAZIDE;caprohydrazide;decanehydrazide
• CAS NO: 20478-70-0
• Molecular Formula: C₁₀H₂₂N₂O
• Molecular Weight: 186.3
• Mol File: 20478-70-0.mol

Chemical Properties

• Boiling Point: 331.2°Cat760mmHg
• Flash Point: 154.1°C
• Appearance: /
• Density: 0.916g/cm³
• Vapor Pressure: 0.000158mmHg at 25°C
• Refractive Index: 1.458
• CAS DataBase Reference: DECANOICACIDHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DECANOICACIDHYDRAZIDE(20478-70-0)
• EPA Substance Registry System: DECANOICACIDHYDRAZIDE(20478-70-0)

Safety Data

• Hazardous Substances Data: 20478-70-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
Decanoic acid hydrazide is used as an intermediate in the synthesis of corrosion inhibitors, plasticizers, and dyes. Its ability to form stable compounds with other chemicals makes it a valuable component in the production of these products.
Used in Fuel Industry:
As a fuel additive, decanoic acid hydrazide enhances the performance and efficiency of fuels. Its addition to fuel formulations can improve combustion characteristics and reduce emissions.
Used in Pharmaceutical Industry:
Decanoic acid hydrazide is utilized as a pharmaceutical intermediate, playing a crucial role in the development of new drugs and medications. Its unique chemical structure allows for the creation of various pharmaceutical compounds with potential therapeutic applications.
Used in Industrial Applications:
In industrial settings, decanoic acid hydrazide is employed in the production of various organic compounds. Its low acute toxicity and general safety for use in industrial and laboratory applications make it a preferred choice for chemical synthesis processes.
Overall, decanoic acid hydrazide's versatility and low toxicity contribute to its widespread use across different industries, including chemical synthesis, fuel production, pharmaceutical development, and industrial applications.

InChI:InChI=1/C10H22N2O/c1-2-3-4-5-6-7-8-9-10(13)12-11/h2-9,11H2,1H3,(H,12,13)

Upstream product

• 110-42-9 Methyl decanoate 
• 110-38-3 decanoic acid ethyl ester 
• 334-48-5 1-decanoic acid 

Downstream Products

• 51707-21-2 3-(decanoylhydrazono-methyl)-rifamycin 
• 114953-92-3 3-Nonyl-5-phenyl-1H-[1,2,4]triazole 
• 101739-63-3 decanoic acid (2-hydroxybenzylidene)hydrazide 
• 1290139-33-1 decanoic acid [2-(4-chlorophenyl)-5-(4-hydroxy-3,5-dimethoxy-benzylidene)-4-oxo-thiazolidin-3-yl]amide 
• 1290139-34-2 decanoic acid [2-(4-methoxyphenyl)-5-(3-nitro-benzylidene)-4-oxo-thiazolidin-3-yl]amide 
• 1290139-35-3 decanoic acid [5-(4-hydroxy-3,5-dimethoxy-benzylidene)-2-(4-methoxy phenyl)-4-oxo-thiazolidin-3-yl]amide 
• 1290139-36-4 decanoic acid [2-(4-hydroxy-3,5-dimethoxy-phenyl)-5-(3-nitro-benzylidene)-4-oxo-thiazolidin-3-yl]amide 
• 1290139-37-5 decanoic acid [5-(4-hydroxy-3,5-dimethoxy-benzylidene)-2-(4-hydroxy-3,5-dimethoxy-phenyl)-4-oxo-thiazolidin-3-yl]amide 
• 1290139-23-9 decanoic acid [4-oxo-2-(3-nitrophenyl)-thiazolidin-3-yl]amide 
• 1290139-24-0 decanoic acid [4-oxo-2-(4-fluorophenyl)-thiazolidin-3-yl]amide 
• 346720-88-5 decanoic acid (4-fluorobenzylidene)hydrazide 

Relevant articles and documents

Concise total synthesis of hydrazidomycin A, a rare hydrazide metabolite of streptomyces atratus

Hydrazidomycins A-C and elaiomycins B-C represent a family of unusual, naturally occurring enehydrazides produced by Streptomyces sp. A general synthetic approach to access these densely functionalized hydrazine derivatives is exemplified by the first total synthesis of hydrazidomycin A. The modular synthesis involves a ruthenium-catalyzed hydroamidation of an alkyne and a hydrazide-derived phthalimide to yield predominantly the Z-configured enehydrazide. Copyright

Microwave irradiated synthesis of Schiff bases of 4-(arylideneamino)-5-alkyl-2,4-dihydro-1,2,4-triazole-3-thione containing 1,2,4-triazole segment

Novel compounds based on the 1,2,4-triazole skeleton were synthesized. A class of 4-amino-5-alkyl-4H-1,2,4-triazole-3-thione created by reaction of thiocarbohydrazide with long-chain aliphatic carboxylic acids, and then the Schiff bases were obtained in the media of heat and microwave waves, in the presence and the absence of a catalyst. Their chemical structures were assayed by elemental analysis, also device spectroscopic methods.

Lipophilic gold(I) complexes with 1,3,4-oxadiazol-2-thione or 1,3-thiazolidine-2-thione moieties: synthesis and their cytotoxic and antimicrobial activities

Novel lipophilic gold(I) complexes containing 1,3,4-oxadiazol-2-thione or 1,3-thiazolidine-2-thione derivatives were synthesized and characterized by IR, high resolution mass spectrometry, and 1H, 13C 31P NMR. The cytotoxicity of the compounds was evaluated considering cisplatin and/or auranofin as reference in different tumor cell lines: colon cancer (CT26WT), metastatic skin melanoma (B16F10), breast adenocarcinoma (MCF-7), cervical carcinoma (HeLa), glioblastoma (M059?J). Normal human lung fibroblasts (GM07492-A) and kidney normal cell (BHK-21) were also evaluated. The gold(I) complexes were more active than their respective free ligands and cisplatin. Furthermore, antibacterial activity was evaluated against Gram-positive bacteria Staphylococcus aureus ATCC 25213, Staphylococcus epidermidis ATCC 12228 and Gram-negative bacteria Escherichia coli ATCC 11229 and Pseudomonas aeruginosa ATCC 27853 and expressed as the minimum inhibitory concentration (MIC). The complexes exhibited lower MIC values when compared to the ligands and chloramphenicol against Gram-positive bacteria and Gram-negative bacteria. Escherichia coli was sensitive one to the action of gold(I) complexes.

Bile acid hydrazides: Gelation, structural, physical and spectroscopic properties

Synthesis and gelation properties of a series of novel bile acid hydrazides are presented. These compounds are found to undergo self-assembly leading to organogelation in certain organic solvents. Compound 1 was found to be the most "effective" gelator in this series. The properties of this gel have been thoroughly investigated by conventional methods typical for molecular gel studies. Sol-gel transition temperature (Tg) of chloroform gels of compounds 1 and 3 was found to increase with increase in the chain length. Sol-gel transition was probed using the isothermal time test and results show that there is instantaneous increase in both the moduli after shear melting, which suggests that the kinetics of formation of the network was very fast. IR and NMR studies revealed hydrogen bonding between amidic carbonyl in the side chain and hydroxyl groups of cholic acid.

Synthesis, antimicrobial evaluation, QSAR and in silico ADMET studies of decanoic acid derivatives

Various derivatives of decanoic acid (CD) have been synthesized and evaluated against Gram positive B. subtilis, S. aureus and Gram negative E. coli bacteria as well as against fungi C. albicans and A. niger. Quantitative structure activity relationship (QSAR) models for antimicrobial activities were developed using multiple linear regression and cross validated by leave one out (LOO) approach. QSAR studies indicated that activity against Gram positive bacteria was governed by lipophilicity of the compounds while topological steric nature of the molecule was deciding factor for antifungal activity. Further, in silico ADMET studies showed that compounds CD12, 19, 20 and 23 could be explored further for other activities.

Synthesis of some novel 2,5-disubstituted thiazolidinones from a long chain fatty acid as possible anti-inflammatory, analgesic and hydrogen peroxide scavenging agents

Some new decanoic acid [2,5-disubstituted-4-oxo-thiazolidin-3-yl]amides (6a-j) have been synthesised by the condensation of decanoic acid hydrazide with various aromatic aldehydes to yield the Schiff's bases. Cyclocondensation of the Schiff's bases with thioglycollic acid afforded 4-thiazolidinone derivatives. The structures of the newly synthesised compounds were confirmed by analytical and spectral methods. The anti-inflammatory, analgesic and antioxidant activity of the title compounds were evaluated. Compound 6j exhibited 44.84 % inhibition of inflammation and was the most potent anti-inflammatory agent of the series whereas compound 6f demonstrated the most potent analgesic activity (69.82% inhibition of writhing) followed by compounds 6e and 6g. All the synthesised compounds exhibited a potent antioxidant activity.

Thiazolidin-4-one and hydrazone derivatives of capric acid as possible anti-inflammatory, analgesic and hydrogen peroxide-scavenging agents

Starting from capric acid, hydrazone and thiazolidin-4-one derivatives have been synthesized in the present investigation. Decanoic acid hydrazide was reacted appropriately to yield hydrazones, which were then cyclized to yield the corresponding thiazolidin-4-ones. The structures of the newly synthesized compounds were confirmed by analytical and spectral methods. Anti-inflammatory, analgesic, and hydrogen peroxide-scavenging activity of the title compounds were evaluated. Among synthesized compounds, 2-hydroxyphenyl thiazolidinone with 44.90% inhibition of inflammation was the most potent anti-inflammatory agent. Similarly, 4-methoxybenzylidine hydrazide with 64.90% inhibition of writhing was observed to be the most potent analgesic agent of the synthesized compounds. All the synthesized compounds exhibited potent hydrogen peroxide-scavenging activity.

Development and assessment of green synthesis of hydrazides

An expeditious, solvent free one pot method for the preparation of hydrazides from corresponding acids directly under microwave irradiation is developed. The method has been assessed using green chemistry measures and found superior to conventional method with higher E(environmental) factor, atom economy, atom efficiency, carbon efficiency, reaction mass efficiency.

Green synthesis of 5-substituted-1,3,4-thiadiazole-2-thiols as new potent nitrification inhibitors [1]

(Chemical Equation Presented) A fast, efficient synthesis of 5-substituted-1,3,4-thiadiazole-2-thiols was successfully developed, assessed using green chemistry matrices, and compounds were screened for their in vitro nitrification inhibitory activity. The greener method was superior with higher energy efficiency, E(nvironmental) factor, atom economy, atom efficiency, carbon efficiency, and reaction mass efficiency.

Glycosylhydrazides, a New Class of Sugar Surfactant. Preparation and Amphiphilic Properties of 1-Glycosyl-2-Acylhydrazines

The synthesis and the amphiphilic properties of 1-glycosyl-2-acylhydrazines are described. This new class of surfactants, referred to as glycosylhydrazides, is easily available from a reducing sugar and hydrazides without protection. Seven hydrazides having an alkyi chain of up to fourteen carbon atoms, arc coupled with glucose giving 1-glucosyl-2-acylhydrazines in good yields; 1-maltosyl-2-octanoylhydrazine, as a typical disaccharide-based surfactant, is prepared as well. Critical micellar concentrations of these surfactants range from 0.04 to 252 mM.