- INHIBITORS OF ADENOSINE 5'-NUCLEOTIDASE
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Compounds that modulate the conversion of AMP to adenosine by 5'- nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment
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Paragraph 0266
(2018/04/21)
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- MODULATORS OF 5'-NUCLEOTIDASE, ECTO AND THE USE THEREOF
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Compounds that modulate the conversion of AMP to adenosine by 5'- nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5'-nucleotidase, ecto is also provided.
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Paragraph 0289
(2017/08/01)
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- Synthesis and Evaluation of 2,6-Modified Purine 2′-C-Methyl Ribonucleosides as Inhibitors of HCV Replication
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A variety of 2,6-modified purine 2′-C-methylribonucleosides and their phosphoramidate prodrugs were synthesized and evaluated for inhibition of HCV RNA replication in Huh-7 cells and for cytotoxicity in various cell lines. Cellular pharmacology and HCV polymerase incorporation studies on the most potent and selective compound are reported.
- Zhou, Longhu,Zhang, Hongwang,Tao, Sijia,Ehteshami, Maryam,Cho, Jong Hyun,McBrayer, Tamara R.,Tharnish, Philip,Whitaker, Tony,Amblard, Franck,Coats, Steven J.,Schinazi, Raymond F.
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supporting information
p. 17 - 22
(2016/02/03)
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- 2'-C-Methyl analogues of selective adenosine receptor agonists: Synthesis and binding studies
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2'-C-Methyl analogues of selective adenosine receptor agonists such as (R)-PIA, CPA, CCPA, NECA, and IB-MECA were synthesized in order to further investigate the subdomain that binds the ribose moiety. Binding affinities of these new compounds at A1
- Franchetti, Palmarisa,Cappellacci, Loredana,Marchetti, Stefano,Trincavelli, Letizia,Martini, Claudia,Mazzoni, Maria R.,Lucacchini, Antonio,Grifantini, Mario
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p. 1708 - 1715
(2007/10/03)
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