205171-10-4

Usage

Uses

Used in Pharmaceutical Development:
2,6-Dichloro-9-(2-C-Methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine is used as a potential drug candidate for its unique chemical structure and properties. 2,6-Dichloro-9-(2-C-Methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine's modifications may allow it to interact with cellular processes in ways that could be harnessed for therapeutic purposes, particularly in the treatment of diseases where nucleic acid metabolism is implicated.
Used in Research Applications:
In the field of molecular biology and genetics, 2,6-Dichloro-9-(2-C-Methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine serves as a valuable research tool. It can be utilized in studies aimed at understanding the mechanisms of nucleic acid synthesis, repair, and regulation, as well as in exploring the effects of nucleoside analogs on cellular processes. 2,6-Dichloro-9-(2-C-Methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine may also be instrumental in the development of new diagnostic tools and therapeutic strategies targeting nucleic acid-related pathways.

Upstream product

• 5451-40-1 2,6 dichloropurine 
• 15397-15-6 1,2,3,5-tetra-O-benzoyl-2-C-methyl-β-D-ribofuranose 
• 492-30-8 2-C-methyl-D-ribono-1,4-lactone 
• 98-88-4 benzoyl chloride 
• 7392-74-7 (3R,4R,5R)-5-((benzoyloxy)methyl)-3-methyl-2-oxotetrahydrofuran-3,4-diyl dibenzoate 
• 30361-17-2 2-methyl-2,3,5-tribenzoyl-ribonolactol 
• 5451-40-1 2,6-dichloro-7H-purine 

Downstream Products

• 849242-02-0 N⁶-(3-iodobenzyl)-2-chloro-9H-(2-C-methyl-2,3-O-isopropylidene-β-D-ribofuranosyl)adenine 
• 849241-80-1 (2R,3R,4R,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol 
• 849241-98-1 (2S,3R,4R,5R)-5-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-3,4-dihydroxy-4-methyl-tetrahydro-furan-2-carboxylic acid methylamide 
• 849242-03-1 1-deoxy-1-[N⁶-(3-iodobenzyl)-2-chloro-9H-purin-9-yl]-2-C-methyl-2,3-O-isopropylidene-β-D-ribofuranoic acid 
• 849242-05-3 ethyl 1-deoxy-1-[N⁶-(3-iodobenzyl)-2-chloro-9H-purin-9-yl]-2-C-methyl-2,3-O-isopropylidene-β-D-ribofuranuroate 
• 622379-96-8 2-chloro-6-methoxy-9-(2-C-methyl-β-D-ribofuranosyl)-9H-purine 

Relevant academic research and scientific papers

INHIBITORS OF ADENOSINE 5'-NUCLEOTIDASE

Compounds that modulate the conversion of AMP to adenosine by 5'- nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment

MODULATORS OF 5'-NUCLEOTIDASE, ECTO AND THE USE THEREOF

Compounds that modulate the conversion of AMP to adenosine by 5'- nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5'-nucleotidase, ecto is also provided.

Synthesis and Evaluation of 2,6-Modified Purine 2′-C-Methyl Ribonucleosides as Inhibitors of HCV Replication

A variety of 2,6-modified purine 2′-C-methylribonucleosides and their phosphoramidate prodrugs were synthesized and evaluated for inhibition of HCV RNA replication in Huh-7 cells and for cytotoxicity in various cell lines. Cellular pharmacology and HCV polymerase incorporation studies on the most potent and selective compound are reported.

2'-C-Methyl analogues of selective adenosine receptor agonists: Synthesis and binding studies

2'-C-Methyl analogues of selective adenosine receptor agonists such as (R)-PIA, CPA, CCPA, NECA, and IB-MECA were synthesized in order to further investigate the subdomain that binds the ribose moiety. Binding affinities of these new compounds at A1