205240-59-1

Basic information

• Product Name: 2-Chloro-3-iodo-6-(trifluoromethyl)pyridine
• Synonyms: 2-Chloro-3-iodo-6-(trifluoromethyl)pyridine;2-Chlor-3-iod-6-trifluormethylpyridine;Pyridine, 2-chloro-3-iodo-6-(trifluoromethyl)-
• CAS NO: 205240-59-1
• Molecular Formula: C6H2ClF3IN
• Molecular Weight: 307.4394596
• Mol File: 205240-59-1.mol

Chemical Properties

• Boiling Point: 233℃
• Flash Point: 94℃
• Appearance: /
• Density: 2.046
• Storage Temp.: 2-8°C
• PKA: -5.14±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-3-iodo-6-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-iodo-6-(trifluoromethyl)pyridine(205240-59-1)
• EPA Substance Registry System: 2-Chloro-3-iodo-6-(trifluoromethyl)pyridine(205240-59-1)

Safety Data

• Hazardous Substances Data: 205240-59-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Chloro-3-iodo-6-(trifluoromethyl)pyridine is utilized as an intermediate in the synthesis of various pharmaceuticals. Its electron-withdrawing properties and the presence of the trifluoromethyl group contribute to the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Production:
In the agrochemical industry, 2-Chloro-3-iodo-6-(trifluoromethyl)pyridine serves as a key intermediate for the production of pesticides and other agrochemicals. Its unique properties allow for the creation of compounds with enhanced pesticidal activity and selectivity, contributing to more effective crop protection.
Used in Organic Chemistry Reactions:
Due to its strong electron-withdrawing nature, 2-Chloro-3-iodo-6-(trifluoromethyl)pyridine is employed in various organic chemistry reactions. It can act as a reagent or catalyst, facilitating the formation of desired products and improving the overall efficiency of the reaction process.

Upstream product

• 39890-95-4 2-chloro-6-trifluoromethylpyridine 

Downstream Products

• 205444-22-0 2-chloro-4-iodo-6-(trifluoromethyl)pyridine 
• 796090-23-8 2-chloro-6-(trifluoromethyl)pyridine-4-carboxylic acid 

Relevant articles and documents

3- (1H-PYRAZOL-4-YL) PYRIDINEALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR

The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL

The present invention relates to pharmaceutical compounds of the Formula (I), or a pharmaceutically acceptable salt or composition thereof, and methods of their use for the treatment of pain, respiratory conditions, as well as inhibiting the Transient Receptor Potential Al ion channel (TRPA1).

AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS

Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, [formula (I) should be inserted here]. Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods

Novel Heterocyclidene Acetamide Derivative

A compound represented by formula (I′): (wherein m, n, and p each represent 0 to 2; q represents 0 or 1; R1 represents halogen, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, a sulfamoyl group, a CN group,

NOVEL HETEROCYCLIDENE ACETAMIDE DERIVATIVE

A compound represented by formula (I'): (wherein m, n, and p each represent 0 to 2; q represents 0 or 1; R1 represents halogen, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, a sulfamoyl group, a CN group,

Halogen shuffling in pyridines: Site selective electrophilic substitutions of 2-chloro-6-(trifluoromethyl)pyridine

When treated with lithium diisopropylamide in tetrahydrofuran at -85 °C and subsequently with iodine, 2-chloro-6-(trifluoromethyl)pyridine is neatly converted into its 3-iodo derivative. The latter can be quantitatively isomerized to afford 2-chloro-4-iodo-6-(trifluoromethyl)pyridine. Either iodo compound can serve as the starting material for further manipulation in reaction sequences consisting of halogen/metal exchange and electrophilic trapping.