796090-23-8

Usage

Uses

Used in Agriculture:
2-chloro-6-(trifluoroMethyl)isonicotinic acid is used as a preand post-emergent herbicide for controlling a wide range of grasses and broadleaf weeds in various crops, such as soybeans and corn. Its selective action on acetolactate synthase ensures effective weed control without harming the target crops, thus improving crop yield and quality.

Upstream product

• 124-38-9 carbon dioxide 
• 205444-22-0 2-chloro-4-iodo-6-(trifluoromethyl)pyridine 
• 205240-59-1 2-chloro-3-iodo-6-(trifluoromethyl)pyridine 
• 1196155-38-0 2-chloro-6-(trifluoromethyl)isonicotinonitrile 
• 39890-95-4 2-chloro-6-trifluoromethylpyridine 

Downstream Products

• 917396-39-5 [2-chloro-6-(trifluoromethyl)pyridin-3-yl]methanol 
• 1196157-41-1 [2-chloro-6-(trifluoromethyl)pyridin-4-yl]methanol 
• 1395416-46-2 2-methylsulfanyl-6-(trifluoromethyl)pyridine-4-carboxylic acid 
• 1060810-89-0 1-(2-chloro-6-(trifluoromethyl)pyridin-4-yl)ethan-1-one 
• 1422457-73-5 {1-(cis-4-{[4-(1-hydroxy-1-methylethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}cyclohexyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile 
• 1422457-74-6 {1-(trans-4-{[4-(1-hydroxy-1-methylethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}cyclo hexyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile 

Relevant academic research and scientific papers

INHIBITORS OF CBL-B AND METHODS OF USE THEREOF

Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo.

CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS

The present invention provides cyclobutyl substituted pyrrolopyrimidines and pyrrolopyridines of Formula I: wherein X, Y, Z, L, A, R5, n and m are defined above, as well as their compositions and methods of use, that modulate the activity of Janus kinases (JAKs) and are useful in the treatment of diseases related to the activity of JAKs including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Heteroaryl and benzyl amide compounds

Compounds of formula I wherein R1, R2, R4, R5, A, B, D and n are as defined, and pharmaceutically acceptable salts thereof, processes for their preparation, their use as pharmaceuticals and pharmaceutical compositions comprising them.

Three chloro(trifluoromethyl)pyridines as model substrates for regioexhaustive functionalization

As a further test of the concept of regioexhaustive functionalization, 2-chloro-6-(trifluoromethyl)pyridine, 2-chloro-5-(trifluoromethyl)pyridine and 3-chloro-4-(trifluoromethyl)-pyridine were each converted into the three possible carboxylic acids 2, 4, 6, 8, 10, 12, 16, 17 and 20. This was achieved by employing several, but not all of the organometallic "tool-box methods": transformation of a more basic organometallic species into a less basic isomer by transmetalation-equilibration, site discriminating deprotonation with lithium N,N-diisopropylamide or lithium 2,2,6,6- tetramethylpiperidide, regio-divergent iodine migration and steric screening of acidic positions by a bulky trialkylsilyl group. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.