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205391-01-1

4,5-DIAMINOFLUORESCEIN, also known as DAF-2, is a sensitive fluorescent indicator used for the detection of nitric oxide (NO). It reacts with NO in the presence of oxygen to yield the highly fluorescent triazolofluorescein (DAF-2T). Fluorescence is monitored using excitation and emission wavelengths of 485 and 538 nM, respectively. At neutral pH, the detection limit for NO is 2-5 nM.

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  • 205391-01-1 Structure

  • Basic information

    1. Product Name: 4,5-DIAMINOFLUORESCEIN
    2. Synonyms: 2-(3,6-DIHYDROXY-9H-XANTHEN-9-YL)-4,5-DIAMINO-BENZOIC ACID;4,5-DIAMINOFLUORESCEIN;DAF-2;5,6-DIAMINOFLUORESCEIN;4,5-Diaminofluorescein, DAF-2;4,5-Diaminofluorescein-Isopropanol adduct (1:2);5-Diaminofluorescein
    3. CAS NO:205391-01-1
    4. Molecular Formula: C20H14N2O5
    5. Molecular Weight: 362.34
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 205391-01-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 4,5-DIAMINOFLUORESCEIN(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4,5-DIAMINOFLUORESCEIN(205391-01-1)
    11. EPA Substance Registry System: 4,5-DIAMINOFLUORESCEIN(205391-01-1)

  • Safety Data

    1. Hazard Codes: Xn,Xi
    2. Statements: 22-36/37/38
    3. Safety Statements: 23-26-36
    4. WGK Germany: 3
    5. RTECS:
    6. F: 8-10-23
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 205391-01-1(Hazardous Substances Data)

205391-01-1 Usage

Uses

Used in Research Applications:
4,5-DIAMINOFLUORESCEIN is used as a highly sensitive reagent for NO detection and determination of nitric oxide synthase activity. It is particularly useful in research settings where accurate and precise measurement of NO levels is required.
Used in Biomedical Applications:
4,5-DIAMINOFLUORESCEIN is used as a fluorescent detector of nitric oxide in culture medium, tissue sections, and biopsy cells. This allows for the visualization and analysis of NO production in various biological samples, aiding in the study of its role in physiological and pathological processes.

Check Digit Verification of cas no

The CAS Registry Mumber 205391-01-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,5,3,9 and 1 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 205391-01:
(8*2)+(7*0)+(6*5)+(5*3)+(4*9)+(3*1)+(2*0)+(1*1)=101
101 % 10 = 1
So 205391-01-1 is a valid CAS Registry Number.

205391-01-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,5-Diaminofluorescein-Isopropanol adduct (1:2)

1.2 Other means of identification

Product number -
Other names 5,6-diamino-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:205391-01-1 SDS

205391-01-1Downstream Products

205391-01-1Relevant articles and documents

Development of a fluorescent indicator for nitric oxide based on the fluorescein chromophore

Kojima, Hirotatsu,Sakurai, Kuniko,Kikuchi, Kazuya,Kawahara, Shigenori,Kirino, Yutaka,Nagoshi, Hiroshi,Hirata, Yasunobu,Nagano, Tetsuo

, p. 373 - 375 (1998)

Endogenous nitric oxide (NO) appears to modulate many physiological and pathophysiological processes. In order to obtain direct evidence for NO functions in vivo, we have developed 4,5-diaminofluorescein (DAF-2) as a novel fluorescent indicator for NO. Gr

Detection and Imaging of Nitric Oxide with Novel Fluorescent Indicators: Diaminofluoresceins

Kojima, Hirotatsu,Nakatsubo, Naoki,Kikuchi, Kazuya,Kawahara, Shigenori,Kirino, Yutaka,Nagoshi, Hiroshi,Hirata, Yasunobu,Nagano, Tetsuo

, p. 2446 - 2453 (2007/10/03)

Nitric oxide is a gaseous, free radical which plays a role as an intracellular second messenger and a diffusable intercellular messenger. To obtain direct evidence for NO functions in vivo, we have designed and synthesized diaminofluoresceins (DAFs) as no

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