205744-17-8

Basic information

• Product Name: 3-Pyridinemethanamine,6-fluoro-(9CI)
• Synonyms: (6-Fluoropyridin-3-yl);5-(Aminomethyl)-2-fluoropyridine;3-Pyridinemethanamine,6-fluoro-(9CI);2-fluoro-5-(aminomethyl)pyridine;6-Fluoro-3-pyridineMethanaMine
• CAS NO: 205744-17-8
• Molecular Formula: C₆H₇FN₂
• Molecular Weight: 126.13
• Product Categories: PYRIDINE
• Mol File: 205744-17-8.mol

Chemical Properties

• Boiling Point: 231.9 °C at 760 mmHg
• Flash Point: 94 °C
• Appearance: /
• Density: 1.18 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.73±0.29(Predicted)
• CAS DataBase Reference: 3-Pyridinemethanamine,6-fluoro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinemethanamine,6-fluoro-(9CI)(205744-17-8)
• EPA Substance Registry System: 3-Pyridinemethanamine,6-fluoro-(9CI)(205744-17-8)

Safety Data

• Hazardous Substances Data: 205744-17-8(Hazardous Substances Data)

Usage

Uses

Used in Agricultural Industry:
3-Pyridinemethanamine,6-fluoro-(9CI) is used as a key intermediate compound for the development of herbicides. It plays a crucial role in the study of herbicidal activity of 2-cyano-3-[[(6-fluoro-3-pyridinyl)methyl]amino]acrylates. These herbicides are designed to control the growth of unwanted plants in agricultural fields, thereby improving crop yield and quality.
In the development of herbicides, 3-Pyridinemethanamine,6-fluoro-(9CI) is used to create novel chemical structures that can effectively target and inhibit specific plant growth processes. 3-Pyridinemethanamine,6-fluoro-(9CI)'s unique properties, such as the presence of a fluorine atom and a secondary amine group, contribute to its potential as a building block for designing new and improved herbicidal agents.
The study of herbicidal activity of 2-cyano-3-[[(6-fluoro-3-pyridinyl)methyl]amino]acrylates involving 3-Pyridinemethanamine,6-fluoro-(9CI) aims to understand the compound's interaction with plant enzymes and its ability to disrupt essential plant metabolic pathways. This knowledge can be utilized to develop more targeted and environmentally friendly herbicides, reducing the impact on non-target organisms and the ecosystem.

Upstream product

• 3939-12-6 6-fluoro-3-pyridinecarbonitrile 
• 105827-74-5 5-(Bromomethyl)-2-fluoropyridine 
• 2369-19-9 2-fluoro-5-methylpyridine 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 864061-60-9 N-(2-fluoro-5-pyridylmethyl)phthalimide 

Downstream Products

• 1135619-76-9 C₂₅H₂₀FN₃O₃ 
• 1135619-66-7 C₂₄H₁₈FN₃O₃ 
• 1135619-62-3 C₂₄H₁₈FN₃O₃ 

Relevant articles and documents

NAMPT/HDAC dual-target inhibitor and preparation method thereof

The invention discloses an NAMPT/HDAC dual-target inhibitor and a preparation method thereof. The dual-target inhibitor is an amide derivative and pharmaceutically acceptable salt thereof, wherein a structure general formula is represented as the formula

Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors

Cancer metabolism and epigenetics are among the most intensely pursued research areas in anticancer drug discovery. Here we report the first small molecules that simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and histone deacetylase (HDAC), two important targets of cancer metabolism and epigenetics, respectively. Through iterative structure-based drug design, chemical synthesis, and biological assays, a highly potent dual NAMPT and HDAC inhibitor was successfully identified. Compound 35 possessed excellent and balanced activities against both NAMPT (IC50 = 31 nM) and HDAC1 (IC50 = 55 nM). It could effectively induce cell apoptosis and autophagy and ultimately led to cell death. Importantly, compound 35 showed excellent in vivo antitumor efficacy in the HCT116 xenograft model. This proof-of-concept study demonstrates the feasibility of discovering an inhibitor targeting cancer metabolism and epigenetics and provides an efficient strategy for multitarget antitumor drug discovery.

Synthesis and herbicidal activity of 2-cyano-3-(2-fluoro-5-pyridyl) methylaminoacrylates

A series of 2-cyano-3-(2-fluoro-5-pyridyl)methylaminoacrylates were synthesized as herbicidal inhibitors of photosystem II (PSII) electron transport. 2-Fluoro-5-pyridinemethylamine was prepared from 2-amino-5- methylpyridine, subsequent reaction with 2-cyano-3,3-dimethylthioacrylates or 2-cyano-3-methoxyacrylates to yield these title compounds. All of these compounds were confirmed by 1H NMR, IR, mass spectrum and elemental analyses. Their herbicidal activities were evaluated. All of the title compounds showed excellent herbicidal activities to amaranth pigweed and rape in post-emergence treatment. At the rate of 150 g/ha, one compound exhibited similar activity to Cl-analogue. The replacement of chlorine by fluorine group showed the same herbicidal activity.