Linear Oligopeptides. 401. In Search of a Peptide 310-Helix in Water
The terminally blocked, sequential oligopeptides of general formula Ac-n-OtBu (n=1-4) have been synthesized by segment condensation in solution and fully characterized.Using CD technique we determined the preferred solution conformation of these hydrosolube oligomers under a variety of experimental conditions.Low populations of α-helical structure are shown by the nonamer and dodecamer in water.The amount of α-helix can be increased by increasing the pH to 12, adding 2,2,2-trifluoroethanol up to 50percent, and decreasing the temperature to 3 deg C.The effect of peptide concentration on conformation is negligible.Under membrrane-mimetic conditions the two highest oligomers appear to fold largely into a 310-helix.The observation of a peptide 310-helix in water remains elusive.Only the dodecamer shows antibacterials activity, although modest.
Get Best Price for205756-79-22-[2-((S)-2-Acetylamino-6-benzyloxycarbonylamino-hexanoylamino)-2-methyl-propionylamino]-2-methyl-propionic acid tert-butyl ester