- Process and intermediate for the purification of oxytetracycline
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The invention relates to a new process for obtaining a completely pure oxytetracycline which does not contain any acetyldecarboxamidooxytetracycline as ingredient. In glacial acetic acid there is suspended under stirring oxytetracycline hydrochloride, or alternatively, oxytetracycline dihydrate under addition of an equimolar quantity of hydrogen chloride in the form of concentrated hydrochloric acid. The stirring is continued for 5 hours, the formed oxytetracycline hydrochloride acetate precipitate is filtered, washed with glacial acetic acid and acetone, whereupon it is dried under reduced pressure at a temperature up to 40° C. till constant weight. Oxytetracycline hydrochloride acetate STR1 is a new compound and may be used as intermediate in the above process.
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- Interaction between Oxytetracycline Sulphosalicylate and Calcium Chloride
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Oxytetracycline sulphosalicylate (OTc-SAA) and calcium chloride react in methanol to furnish a product characterised as oxytetracycline hydrochloride (OTc.HCl) by spectrophotometric technique and other supporting evidences.This constitutes a novel method in the field of tetracyclines wherein isolation of substantially pure OTc.HCl in ca. 80percent yield is achieved without employing hydrochloric acid.
- Issar, M. M.,Mahadevan, P. R.
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p. 257 - 258
(2007/10/02)
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