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| CAS No.: | 2058-46-0 |
|---|---|
| Name: | Oxytetracycline hydrochloride |
| Article Data: | 2 |
| Molecular Structure: | |
|
|
|
| Formula: | C22H25ClN2O9 |
| Molecular Weight: | 496.901 |
| Synonyms: | 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-,monohydrochloride, [4S-(4a,4aa,5a,5aa,6b,12aa)]-;1-Dimethylamino-1,4,6,11,12,13,14,18-octahydro-2,5,7,11,12,14-hexahydroxy-4,6-dioxo-11-methylnaphthacene-3-carbonamidehydrochloride;5-Hydroxytetracycline hydrochloride;5-Hydroxytetracyclinemonohydrochloride;Alamycin;Aquacycline;Duphacycline;Engemycin;Gynamousse;Mepatar;Oxy WS;Oxy-Dumocyclin;Oxybiotic;Oxycyclin;Oxypan;Oxytet;Oxytetrin;TM 5;Terraject;Terramycin hydrochloride;Tetra-Tabilinen;Tetran hydrochloride;Toxinal;Vetilmicin; |
| EINECS: | 218-161-2 |
| Density: | == |
| Melting Point: | 180 °C |
| Boiling Point: | 845.6 °C at 760 mmHg |
| Flash Point: | 465.2 °C |
| Solubility: | >100 g/L in water |
| Appearance: | Yellow crystalline solid |
| Hazard Symbols: |
 Xn,  Xi
|
| Risk Codes: | 63-36-36/37/38 |
| Safety: | 36/37/39-26-36 |
| PSA: | 201.85000 |
| LogP: | 0.25870 |
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- 2058-46-0
oxytetracycline hydrochloride
| Conditions | Yield |
|---|---|
| With calcium chloride In methanol at 60℃; | 80% |
| Conditions | Yield |
|---|---|
| In ethanol for 8h; Reflux; | 75% |
| Conditions | Yield |
|---|---|
| In ethanol for 8h; Reflux; | 65% |
- 2058-46-0
oxytetracycline hydrochloride
| Conditions | Yield |
|---|---|
| In ethanol excess of C22H23N2O9*HCl used; | |
| In water excess of C22H23N2O9*HCl used; | |
| In further solvent(s) excess of C22H23N2O9*HCl used, solvent: methyl cellosolve; |
| Conditions | Yield |
|---|---|
| In ammonia; water pH=9; |
- 2058-46-0
oxytetracycline hydrochloride
A
- 471-47-6
oxamic acid
B
- 144-62-7
oxalic acid
C
- 108-24-7
acetic anhydride
D
- 110-16-7
maleic acid
E
- 110-17-8
(2E)-but-2-enedioic acid
| Conditions | Yield |
|---|---|
| With water; sodium sulfate pH=7; Electrochemical reaction; |
| Conditions | Yield |
|---|---|
| With sulfur-doped CoFe2O4 nanopowders In water at 20℃; for 5h; pH=8.5; Kinetics; pH-value; Irradiation; |
- 2058-46-0
oxytetracycline hydrochloride
| Conditions | Yield |
|---|---|
| Stage #1: bismuth (III) nitrate pentahydrate; oxytetracycline hydrochloride In water for 0.5h; Stage #2: at 160℃; for 16h; Autoclave; Stage #3: at 350℃; for 3h; Calcination; |
- 2058-46-0
oxytetracycline hydrochloride
| Conditions | Yield |
|---|---|
| Stage #1: bismuth (III) nitrate pentahydrate; oxytetracycline hydrochloride In water for 0.5h; Stage #2: at 160℃; for 16h; Autoclave; Stage #3: at 300℃; for 3h; Calcination; |
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Chemistry
Empirical Formula: C22H25ClN2O9
Molecular Weight: 496.8949
EINECS: 218-161-2
Flash Point: 394 °C
Enthalpy of Vaporization: 111.54 kJ/mol
Boiling Point: 727.8 °C at 760 mmHg
Vapour Pressure: 3.09E-22 mmHg at 25°C
Melting point: 180 °C
Storage tempreture: 0-6 °C
Water solubility: >100 g/L
Appearance: Yellow crystalline solid
Structure of Oxytetracycline hydrochloride (CAS NO.2058-46-0):
IUPAC Name: (2Z,4S,4aR,5S,5aR,6S,12aS)-2-[Amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione hydrochloride
Product Category of Oxytetracycline hydrochloride (CAS NO.2058-46-0): Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Antibacterial;Antibiotics;Antibiotics by Application;Chemical Structure Class;Genetic Marker SelectionAntibiotics;Mechanism of Action
Uses
Oxytetracycline hydrochloride (CAS NO.2058-46-0) can be used for antibiotic substance isolated from the elaboration products of the actinomycete, Streptomyces rimosus, grown on a suitable medium.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 100mg/kg (100mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Annals of the New York Academy of Sciences. Vol. 53, Pg. 238, 1950. |
| mouse | LD50 | intravenous | 100mg/kg (100mg/kg) | "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 490, 1967. | |
| mouse | LD50 | oral | 6696mg/kg (6696mg/kg) | Annals of the New York Academy of Sciences. Vol. 53, Pg. 238, 1950. | |
| mouse | LD50 | subcutaneous | 600mg/kg (600mg/kg) | Annals of the New York Academy of Sciences. Vol. 53, Pg. 245, 1950. | |
| rabbit | LDLo | intravenous | 80mg/kg (80mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 234, 1950. |
| rat | LD50 | intravenous | 302mg/kg (302mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 234, 1950. | |
| rat | LD50 | subcutaneous | 800mg/kg (800mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 711, 1959. |
Safety Profile
Hazard Codes: 
Xn,
Xi
Risk Statements: 63-36-36/37/38
R36:Irritating to eyes.
R36/37/38:Irritating to eyes, respiratory system and skin.
R63:Possible risk of harm to the unborn child.
Safety Statements: 36/37/39-26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
Specification
Oxytetracycline hydrochloride , its cas register number is 2058-46-0. It also can be called 5-Hydroxytetracycline hydrochloride ; Oxytetracycline HCl ; and [4S-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, Oxytetracycline hydrochloride (CAS NO.2058-46-0) is sensitive to light and air, and may discolor on exposure to air and light. It is not compatible with strong oxidizing agents, bases, and you must not take it with incompatible materials, light, exposure to air, exposure to moist air or water. And also prevent it to broken down into hazardous decomposition products: irritating and toxic fumes and gases. hydrogen chloride, carbon monoxide, carbon dioxide.
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