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205807-59-6

N1-[2,2-Dimethyl-1(S)-(N-methylcarbamoyl)propyl]-N4-hydroxy-3(R)-(hydroxymethyl)-2(S)-(4-methoxyphenyl)succinamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 205807-59-6 Structure

  • Basic information

    1. Product Name: N1-[2,2-Dimethyl-1(S)-(N-methylcarbamoyl)propyl]-N4-hydroxy-3(R)-(hydroxymethyl)-2(S)-(4-methoxyphenyl)succinamide
    2. Synonyms: SDZ-242-484; PKF-242-484
    3. CAS NO:205807-59-6
    4. Molecular Formula: C19H29N3O6
    5. Molecular Weight: 395.45948
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 205807-59-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N1-[2,2-Dimethyl-1(S)-(N-methylcarbamoyl)propyl]-N4-hydroxy-3(R)-(hydroxymethyl)-2(S)-(4-methoxyphenyl)succinamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N1-[2,2-Dimethyl-1(S)-(N-methylcarbamoyl)propyl]-N4-hydroxy-3(R)-(hydroxymethyl)-2(S)-(4-methoxyphenyl)succinamide(205807-59-6)
    11. EPA Substance Registry System: N1-[2,2-Dimethyl-1(S)-(N-methylcarbamoyl)propyl]-N4-hydroxy-3(R)-(hydroxymethyl)-2(S)-(4-methoxyphenyl)succinamide(205807-59-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 205807-59-6(Hazardous Substances Data)

205807-59-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 205807-59-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,5,8,0 and 7 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 205807-59:
(8*2)+(7*0)+(6*5)+(5*8)+(4*0)+(3*7)+(2*5)+(1*9)=126
126 % 10 = 6
So 205807-59-6 is a valid CAS Registry Number.

205807-59-6Downstream Products

205807-59-6Relevant articles and documents

Process development of a dual MMP/TNF inhibitor (SDZ 242-484)

Koch, Guido,Kottirsch, Georg,Wietfeld, Bernhard,Kuesters, Ernst

, p. 652 - 659 (2013/09/06)

The compound (2R,3S)-N-4-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-N-1-hydroxy-2- hydroxymethyl-3-(4-methoxy-phenyl)-succinamide (1; SDZ 242-484) shows antiinflammatory effects due to inhibition of matrix metalloproteases (MMP) and tumor necrosis factor

β-aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme

Kottirsch, Georg,Koch, Guido,Feifel, Roland,Neumann, Ulf

, p. 2289 - 2293 (2007/10/03)

Novel hydroxamate inhibitors of tumor necrosis factor converting enzyme (TACE) and matrix metalloproteases (MMPs) have been synthesized via the Claisen-Ireland rearrangement. Aryl residues have been introduced to fill the enzyme's P1′ specificity pocket. The best compound inhibits MMPs and TACE with nanomolar potency and inhibits the release of TNFα from cells with an IC50 of 48 nM. Oral administration to rats inhibits the LPS-induced plasma TNFα levels with an ED50 of 1 mg/kg.

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