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N1-benzyloxy-2(R)-benzyloxymethyl-N4-(2,2-dimethyl-1(S)-methylcarbamoylpropyl)-3(S)-(4-methoxyphenyl)succinamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

439112-52-4

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439112-52-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 439112-52-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,9,1,1 and 2 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 439112-52:
(8*4)+(7*3)+(6*9)+(5*1)+(4*1)+(3*2)+(2*5)+(1*2)=134
134 % 10 = 4
So 439112-52-4 is a valid CAS Registry Number.

439112-52-4Downstream Products

439112-52-4Relevant academic research and scientific papers

β-aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme

Kottirsch, Georg,Koch, Guido,Feifel, Roland,Neumann, Ulf

, p. 2289 - 2293 (2007/10/03)

Novel hydroxamate inhibitors of tumor necrosis factor converting enzyme (TACE) and matrix metalloproteases (MMPs) have been synthesized via the Claisen-Ireland rearrangement. Aryl residues have been introduced to fill the enzyme's P1′ specificity pocket. The best compound inhibits MMPs and TACE with nanomolar potency and inhibits the release of TNFα from cells with an IC50 of 48 nM. Oral administration to rats inhibits the LPS-induced plasma TNFα levels with an ED50 of 1 mg/kg.

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