cas 206258-97-1, 8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester | Articles data ｜lookchem

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206258-97-1

Articles about 206258-97-1Total 6 be found

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BICYCLIC DERIVATIVES FOR TREATING ENDOPARASITES
The present invention provides compounds of formula (I): which are useful in the control of endoparasites, for example heartworms, in warm-blooded animals.
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(2020/12/29)

QUINOLINE DERIVATIVES FOR TREATING INFECTIONS WITH HELMINTHS
The present invention covers quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate c
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(2019/02/15)

PROCESS FOR PREPARING ANTIHELMINTIC 4-AMINO-QUINOLINE-3-CARBOXAMIDE DERIVATIVES
The present invention relates to a new process for preparing quinoline compounds of the general formula (II): in which Q, A, R4, R3 and R3',are as defined herein, as well as to the intermediate compounds of said new process.
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(2019/07/19)

A four-ring quinolinone alkaloid derivative and its preparation method and application (by machine translation)
The invention relates to a four-ring quinolinone alkaloid derivative, or a tautomer thereof, stereo isomer, racemate, enantiomer of non-isometric mixture, geometric isomer, solvate, pharmaceutically acceptable salt or prodrug, and pharmaceutical composition containing the compound. The invention also discloses such compounds and pharmaceutical compositions thereof as a medicament, in particular as anti-virus, antibacterial and the anti-parasitic drug use. (by machine translation)
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(2018/10/27)

BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS
The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.
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(2013/08/28)

Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors
Potent and selective bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors were synthesized by a novel convergent route. Selectivity and efficacy versus MMPs and TACE could be controlled by appropriate substitution on the scaffolds and by variation of the P1′ group. Select compounds were found to be effective in in vivo models of arthritis.
Zask,Gu,Albright,Du,Hogan,Levin,Chen,Killar,Sung,DiJoseph,Sharr,Roth,Skala,Jin,Cowling,Mohler,Barone,Black,March,Skotnicki
p. 1487 - 1490
(2007/10/03)

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Chemical Properties

Boiling Point: 378.3ºC at 760 mmHg
Flash Point:182.6ºC
Density: 1.578g/cm3
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Vapor Pressure: 6.33E-06mmHg at 25°C
PSA: 39.19000
LogP: 3.82740

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