206258-97-1

Usage

Uses

Used in Pharmaceutical Industry:
8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester is used as an intermediate in the synthesis of pharmaceuticals for its potential biological activities and unique structure, contributing to the development of new drug candidates.
Used in Agrochemical Industry:
8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester is used as an intermediate in the synthesis of agrochemicals, potentially contributing to the development of new pesticides and herbicides for agricultural use.
Used in Organic Chemistry Research:
8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester is used as a valuable building block in medicinal chemistry research, facilitating the exploration of its potential applications and properties in the synthesis of various organic compounds.

InChI:InChI=1/C12H9BrClNO2/c1-2-17-12(16)8-6-15-11-7(10(8)14)4-3-5-9(11)13/h3-6H,2H2,1H3

Upstream product

• 35975-57-6 ethyl-8-bromo-4-hydroxyquinolyl-3-carboxylic acid ethyl ester 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 692764-07-1 ethyl 8-bromo-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 40516-46-9 diethyl (ethoxymethylene)malonate 
• 615-36-1 2-bromoaniline 

Downstream Products

• 206258-99-3 8-bromo-4-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-quinoline-3-carboxylic acid ethyl ester 
• 287379-47-9 ethyl 8-bromo-4-[{[4-(2-butynyloxy)phenyl]sulfonyl}(methyl)amino]-3-quinolinecarboxylate 
• 1449737-48-7 8-bromo-4-((4-methoxybenzyl)amino)quinoline-3-carboxylic acid 
• 1449737-49-8 8-bromo-N-(4-methoxybenzyl)quinolin-4-amine 
• 1449737-47-6 ethyl 8-bromo-4-((4-methoxybenzyl)amino)quinoline-3-carboxylate 
• 1449736-79-1 N⁴-(4-methoxybenzyl)-N⁸-(3-(trifluoromethyl)phenyl)quinoline-4,8-diamine 
• 1449736-78-0 N⁸-(3-(trifluoromethyl)phenyl)quinoline-4,8-diamine 
• 1449735-97-0 2-chloro-5-(pivalamidomethyl)-N-(8-((3-(trifluoromethyl)phenyl)amino)quinolin-4-yl)benzamide 
• 287379-48-0 8-bromo-4-[{[4-(2-butynyloxy)phenyl]sulfonyl} (methyl)-amino]-3-quinolinecarboxylic acid 
• 206258-26-6 4-[methyl-(4-methoxy-benzenesulfonyl)-amino]-8-bromo-quinoline-3-carboxylic acid 

Relevant academic research and scientific papers

BICYCLIC DERIVATIVES FOR TREATING ENDOPARASITES

The present invention provides compounds of formula (I): which are useful in the control of endoparasites, for example heartworms, in warm-blooded animals.

PROCESS FOR PREPARING ANTIHELMINTIC 4-AMINO-QUINOLINE-3-CARBOXAMIDE DERIVATIVES

The present invention relates to a new process for preparing quinoline compounds of the general formula (II): in which Q, A, R4, R3 and R3',are as defined herein, as well as to the intermediate compounds of said new process.

QUINOLINE DERIVATIVES FOR TREATING INFECTIONS WITH HELMINTHS

The present invention covers quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate c

A four-ring quinolinone alkaloid derivative and its preparation method and application (by machine translation)

The invention relates to a four-ring quinolinone alkaloid derivative, or a tautomer thereof, stereo isomer, racemate, enantiomer of non-isometric mixture, geometric isomer, solvate, pharmaceutically acceptable salt or prodrug, and pharmaceutical composition containing the compound. The invention also discloses such compounds and pharmaceutical compositions thereof as a medicament, in particular as anti-virus, antibacterial and the anti-parasitic drug use. (by machine translation)

BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS

The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.

Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors

Potent and selective bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors were synthesized by a novel convergent route. Selectivity and efficacy versus MMPs and TACE could be controlled by appropriate substitution on the scaffolds and by variation of the P1′ group. Select compounds were found to be effective in in vivo models of arthritis.