cas 206278-26-4, 2-Fluoro-3-iodopyrazine | Articles data

Articles about 206278-26-4Total 5 be found

HETEROARYLOXYHETEROCYCLYL COMPOUNDS AS PDE10 INHIBITORS
Heteroaryloxyheterocyclyl compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive-compulsive disorder, and the like.
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Page/Page column 79

(2011/12/02)

PYRAZINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS
Pyrazine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
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Page/Page column 199

(2010/06/15)

AMINOPYRIDINE AND CARBOXYPYRIDINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS
Pyridine and pyrimidine compounds: or a pharmaceutically acceptable salt thereof, wherein m, n, R1, R2, R3, R4, R5, R6, R7, X1, X2, X3, X4, X5, X6, X7, X8, and Y are as defined in the specification; or a pharmaceutically acceptable salt thereof, wherein ring A, m, n, y, R2, R3, R4, R5, R6, R7, R8, R9, X1, X2, and ring A are as defined in the specification; and or a pharmaceutically acceptable salt thereof, wherein m, n, y, R2, R3, R4, R5, R6, R7, R9, X1, X2, and ring A are as defined in the specification; compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
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Page/Page column 167; 168

(2010/07/04)

Regioselective synthesis and metallation of fluoroiodopyrazines. Application to the synthesis of aryl and alkylbenzylpyrazines. Diazines. Part 31
The regioselective metallation of 2-fluoropyrazine allowed the synthesis of various 5- and 6-iodoflouropyrazines. Use of cross-coupling reactions with iodoflouropyrazines under Suzuki or Negishi conditions led to aryl and alkylflouropyrazines. The benzylf
Toudic, Frédéric,Plé, Nelly,Turck, Alain,Quéguiner, Guy
p. 283 - 293
(2007/10/03)

Functionalization by metallation of fluoropyrazine. Diazines XXI
Lithiation of fluoropyrazine followed by quenching with various electrophiles was successfully achieved and was used to synthesize new pyrazine derivatives. A further lithiation of 2-fluoro-3-substitute, pyrazines allowed access to 2,3,6-trisubstituted pyridazine derivatives. As an application, a one-pot synthesis of a quinuclidinylfluoropyrazine has been performed. When the 3-substituent bears a TMS protected alcohol, functionalization via metallation at C6 position provides tetrasubstituted pyrazines in good yield.
Ple, Nelly,Turck, Alain,Heynderickx, Arnault,Queguiner, Guy
p. 4899 - 4912
(2007/10/03)