A new approach to the synthesis of functionalized pyrido[2,3-b]indoles by way of a palladium-catalyzed ring closing reaction between the N-1 and C- 9a positions
The enolate of 4-N-(tert-butyloxycarbonyl)aminobutyro-γ-lactone 9 reacted with 2-bromo-1methylindole-3-carboxaldehyde in the presence of stannic chloride to give the product of aldol condensation 16. Deprotection and dehydration of the latter with trifluo
Abouabdellah, Ahmed,Dodd, Robert H.
p. 2119 - 2122
(2007/10/03)
Isoindoline derivatives
Optically active 8-methoxyquinolonecarboxylic acids represented by the formula (I) wherein R1 is lower alkyl have been found to possess potent antibacterial activity against both Gram-negative and Gram-positive bacteria. The compounds may be synthesized from novel optically active intermediates.
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(2008/06/13)
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