- MONOACYLGLYCEROL LIPASE MODULATORS
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3.1.0 and 4.1.0 Azabicycle compounds of Formula (I), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, su
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Page/Page column 86
(2021/08/20)
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- Borocyclopropanation of Styrenes Mediated by UV-light Under Continuous Flow Conditions
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Herein, we report a user-friendly and metal-free UV-A light mediated borocyclopropanation of styrenes using continuous flow technology. A broad range of styrene derivatives can be cyclopropanated in good yields within 1 h residence time to produce highly
- Sayes, Morgane,Benoit, Guillaume,Charette, André B.
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p. 13514 - 13518
(2018/09/25)
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- Synthesis of Borylcyclopropanes by Chromium-Promoted Cyclopropanation of Unactivated Alkenes
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The combination of diiodomethylboronate ester, CrCl2 with TMEDA promoted borylcyclopropanation of unactivated alkenes under mild conditions. Compared with the typical Simmons-Smith cyclopropanation, the current protocol offers the following adv
- Murai, Masahito,Mizuta, Chisato,Taniguchi, Ryuji,Takai, Kazuhiko
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p. 6104 - 6107
(2017/11/27)
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- Diastereoselective borocyclopropanation of allylic ethers using a boromethylzinc carbenoid
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A borocyclopropanation of (E)- and (Z)-allylic ethers and styrene derivatives via the Simmons-Smith reaction using a novel boromethylzinc carbenoid is described. The carbenoid precursor is prepared via a 3-step sequence from inexpensive and commercially available starting materials. This methodology allows for the preparation of 1,2,3-substituted borocyclopropanes in high yields and diastereoselectivities. Several postfunction-alization reactions were also performed to illustrate the versatility of these building blocks.
- Benoit, Guillaume,Charette, André B.
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supporting information
p. 1364 - 1367
(2017/02/10)
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