- METHOD FOR THE PREPARATION OF A COMPOUND OF THE GENERAL FORMULA R1-R1 AND/OR R1-R2 USING HOMO AND HETERO COUPLING REACTIONS
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The present application relates to a method for the preparation of a compound of the general formula R1-R2 (I) and/or R1-R1 (II) comprising providing a compound of the general formula R1dM1Am.zM4Zn (III) or R1R2M1R3kAm.xM4Zn (IV) or R1M1R2R3kM2Am.xM4Zn (V) or R1M3R2M1.xM4Zn (VI) and reacting this compound III-VI with a quinone to produce a compound of the general formula (I) or (II) or a mixture of compounds (I) and (II). The coupling reaction can be used to prepare homo and/or hetero coupling products from well known starting materials using a quinone as redox reagent. The quinone may be recycled from the reaction.
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Page/Page column 15
(2010/11/29)
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- Diastereoselective addition of organomanganese compounds to α-alkoxysubstituted propanals
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Reactions of organomanganese compounds R1MnI (R1 = Ph, 4-MeC6H4, Me, Bu, n-C7H15, BuCC, PhCC),prepared from R1Li and MnI2 in Et2O, with aldehydes MeCH(OR2)CHO (R2 = CH2Ph, CH2OMe, CH2OCH2Ph) afford threo-alcohols MeCH(OR2)CH(OH)R1 with high diastereoselec
- Kasatkin, A. N.,Biktimirov, R. Kh.,Podlipchuk, I. P.,Sultanmuratova, V. R.,Tolstikov, G. A.
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p. 161 - 165
(2007/10/02)
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- TRANSITION METAL ?-COMPLEXES IN ORGANIC SYNTHESIS 5. CROSS-COUPLING OF ORGANOMANGANESE COMPOUNDS WITH ALKENYL IODIDES
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Aryl organomanganese compounds ArMnX and Ph3MnLi (Ar = Ph, p-MeC6H4, p-MeOC6H4, p-ClC6H4, p-BrC6H4, α-naphthyl; X = Cl, Br) react with alkenyl iodides RR1C=CR2I (R = H, Pr, Bu, i-Bu, C6H13, CH2=CHCH2, Ph; R1 = H, Pr, C5H11; R2 = H, Pr, SiMe3) in THF at 0-20 deg C to give cross-coupling products RR1C=CR2Ar in high yields.
- Kasatkin, A. N.,Romanova, T. Yu.,Tsypyshev, O. Yu.,Tolstikov, G. A.,Lomakina, S. I.
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p. 2410 - 2415
(2007/10/02)
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