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4-Bromo-2-iodophenol, with the molecular formula C6H4BrIO, is a chemical compound derived from phenol. It is characterized by its high reactivity and unique structure, making it a valuable building block in the synthesis of complex molecules. 4-BROMO-2-IODOPHENOL is widely used in various organic synthesis processes, particularly in the pharmaceutical and agrochemical industries, as well as in research laboratories for conducting chemical and biological experiments.

207115-22-8

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207115-22-8 Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-2-iodophenol is used as a key intermediate in the synthesis of pharmaceutical compounds for [application reason]. Its high reactivity and unique structure enable the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 4-Bromo-2-iodophenol is utilized as a building block for the production of agrochemicals, such as pesticides and herbicides, for [application reason]. Its incorporation into these compounds enhances their effectiveness in controlling pests and weeds, contributing to increased crop yields and protection.
Used in Research Laboratories:
4-Bromo-2-iodophenol serves as a versatile reagent in research laboratories for conducting various chemical and biological experiments. Its unique properties make it suitable for use in [application reason], such as studying reaction mechanisms, testing hypotheses, and developing new methodologies in chemical synthesis and analysis.
Used in Material Science:
In the field of material science, 4-Bromo-2-iodophenol is employed as a component in the development of new materials and compounds for a wide range of industrial applications. Its unique structure and properties contribute to the creation of innovative materials with enhanced properties, such as improved stability, reactivity, or selectivity, for use in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 207115-22-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,7,1,1 and 5 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 207115-22:
(8*2)+(7*0)+(6*7)+(5*1)+(4*1)+(3*5)+(2*2)+(1*2)=88
88 % 10 = 8
So 207115-22-8 is a valid CAS Registry Number.
InChI:InChI=1S/C6H4BrIO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H

207115-22-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-BROMO-2-IODOPHENOL

1.2 Other means of identification

Product number -
Other names 4-bromoiodophenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:207115-22-8 SDS

207115-22-8Relevant articles and documents

One-Pot Benzo[b]phosphole Synthesis through Sequential Alkyne Arylmagnesiation, Electrophilic Trapping, and Intramolecular Phospha-Friedel-Crafts Cyclization

Wu, Bin,Chopra, Rena,Yoshikai, Naohiko

, p. 5666 - 5669 (2015)

A one-pot multicomponent synthesis of a benzo[b]phosphole derivative has been achieved by a sequence of transition-metal-catalyzed arylmagnesiation of an internal alkyne, electrophilic trapping of the resulting alkenylmagnesium species with a dichloroorganophosphine, and an intramolecular phospha-Friedel-Crafts reaction. With appropriate arylmagnesiation and P-C bond formation conditions, the present method allows for the modular and expedient preparation of benzophospholes bearing a variety of substituents on the phosphorus atom, the C2 and C3 atoms, and the benzo moiety.

Halogenated method of aromatic compound

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Paragraph 0208-0210, (2021/11/10)

The invention belongs to the field of organic synthesis, and particularly relates to synthesis of aromatic halogens, in particular to arylamine. The invention discloses a synthesis method of a corresponding ortho-halogenated product from aromatic compounds such as carbazole and phenol. The method comprises the following steps: adding a metal sulfonate salt catalyst, aromatic amine, carbazole, phenol and other hydrogen - heteroatom-containing aromatic compound reaction substrates, a halogenation reagent and a reaction solvent at a specific reaction temperature. After the drying agent is dried, the yield of the reaction product and the nuclear magnetic characterization determining structure are determined by column chromatography. The reaction product yield is determined by gas chromatography. By adopting the method, under the cheap metal salt catalyst, a plurality of ortho-substituted brominated and chloro products can be obtained with moderate to excellent yield.

A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide

Wu, Yong-Qi,Lu, Hai-Jia,Zhao, Wen-Ting,Zhao, Hong-Yi,Lin, Zi-Yun,Zhang, Dong-Feng,Huang, Hai-Hong

supporting information, p. 813 - 822 (2020/02/15)

A convenient, rapid H2SO4-promoted regioselective monobromination reaction with N-bromosuccinimide was developed. The desired para-monobrominated or ortho-monobrominated products of phenol derivatives were obtained in good to excellent yields with high selectivity. Regioselective chlorination and iodination were also achieved in the presence of H2SO4 using N-chlorosuccinimide and N-iodosuccinimide, respectively.

Regioselective monobromination of phenols with KBr and ZnAl–BrO3?–layered double hydroxides

Wang, Ligeng,Feng, Chun,Zhang, Yan,Hu, Jun

supporting information, (2020/02/22)

The regioselective mono-bromination of phenols has been successfully developed with KBr and ZnAl–BrO3?–layered double hydroxides (abbreviated as ZnAl–BrO3?–LDHs) as brominating reagents. The para site is much favorable and the ortho site takes the priority if para site is occupied. This reaction featured with excellent regioselectivity, cheap brominating reagents, mild reaction condition, high atom economy, broad substrate scope, and provided an efficient method to synthesize bromophenols.

Isoquinolinium Dichromate and Chlorochromate as Efficient Catalysts for Oxidative Halogenation of Aromatic Compounds under Acid-Free Conditions

Rao, A. Sambashiva,Rajanna,Reddy, K. Rajendar,Kulkarni, Subhash

, p. 832 - 837 (2016/02/12)

Isoquinolinium dichromate and isoquinolinium chlorochromate were found as efficient catalysts to trigger oxidative bromination and iodination of aromatic hydrocarbons with KBr/KI and KHSO4 under acid-free conditions. Reaction times reduced highly significantly under sonication, followed by corresponding mono bromo derivatives in very good yield with high regioselectivity.

New synthetic routes to thyroid hormone analogs: d6-sobetirome, 3H-sobetirome, and the antagonist NH-3

Placzek, Andrew T.,Scanlan, Thomas S.

, p. 5946 - 5951 (2015/08/04)

Abstract New synthetic routes for the preparation of isotopically labeled versions of thyroid hormone agonist sobetirome were developed using Knochel's iodine-magnesium exchange. A more efficient synthesis of the thyroid hormone antagonist NH-3 was develo

INHIBITORS OF FATTY ACID AMIDE HYDROLASE

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Paragraph 1218; 1219, (2016/01/15)

The present invention provides compounds, and pharmaceutically acceptable compositions thereof, encompassed by any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof. The present invention also provides methods for treating an FAAH mediated disease, disorder or condition by administering a therapeutically effective amount of a compound or composition comprising a compound of any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof, to a patient in need thereof. Additionally, the present invention provides methods for inhibiting FAAH by administering a therapeutically effective amount of a compound or composition comprising a compound of any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof, to a patient in need thereof.

2,2′-biphenols via protecting group-free thermal or microwave-accelerated suzuki-miyaura coupling in water

Schmidt, Bernd,Riemer, Martin,Karras, Manfred

, p. 8680 - 8688 (2013/09/24)

User-friendly protocols for the protecting group-free synthesis of 2,2′-biphenols via Suzuki-Miyaura coupling of o-halophenols and o-boronophenol are presented. The reactions proceed in water in the presence of simple additives such as K2CO3, KOH, KF, or TBAF and with commercially available Pd/C as precatalyst. Expensive or laboriously synthesized ligands or other additives are not required. In the case of bromophenols, efficient rate acceleration and short reaction times were accomplished by microwave irradiation.

One-pot synthesis of 2,2′-bisbenzofurans using cuprous chloride as a catalyst

Pan, Wen-Bin,Chen, Chin-Chau,Wei, Li-Lan,Wei, Li-Mei,Wu, Ming-Jung

, p. 2655 - 2657 (2013/06/05)

A variety of novel 5,5′-disubstituted-2,2′-bisbenzofuran derivatives were synthesized by treatment of 4-substituted-2-(2- trimethylsilylethynyl)phenyl tert-butyldimethylsilyl ether analogues with CuCl as a catalyst in 62-82% isolated yields. This novel st

Novel amines as histamine-3 receptor ligands and their therapeutic applications

-

, (2008/06/13)

Compounds of formula (I) or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the treatment of disorders ameliorated by histamine-3 receptor ligands.

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