- Emimycin and its nucleoside derivatives: Synthesis and antiviral activity
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The synthesis of emimycin, 5-substituted emimycin analogues and the corresponding ribo- and 2′-deoxyribonucleoside derivatives is described. Emimycin, its 5-substituted congeners and the ribonucleoside derivatives are completely devoid of antiviral activity against RNA viruses. In contrast, some of the 2′-deoxyribosyl emimycin derivatives are potent inhibitors of the replication of herpes simplex virus-1 and varicella-zoster virus, lacking cytotoxicity.
- Plebanek, Elzbieta,Lescrinier, Eveline,Andrei, Graciela,Snoeck, Robert,Herdewijn, Piet,De Jonghe, Steven
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- ANTIVIRAL AGENT
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The present invention provides an integrase inhibitor. The inventors have have found the following compound of formula (I) possessing an integrase inhibitory activity. (wherein, R C and R D taken together with the neighboring carbon atoms form a ring which may be a condensed ring, Y is hydroxy, mercapto or amino; Z is O, S or NH ; R A is a group shown by (wherein, C ring is N-containing aromatic heterocycle) or the like)
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Page 177; 178
(2010/02/06)
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- BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
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The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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Page/Page column 57-58
(2010/02/07)
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- At-hydroxyamide-containing heterocycles. Part 7. Preparation and photochemical behavior of 1-benzyloxy-2(1H)-pyrazinones
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Synthesis of 1-benzyloxy-2(1H)-pyrazinones having substituents at C-5 and C-6 positions and their photochemical behavior have been studied. Upon irradiation 1-benzyloxy-2(1H)-pyrazmones underwent N-O bond cleavage in high quantum yields. The rearrangement of the benzyioxy group to C-3 position of the ring and [2+2] cycloaddition were also observed.
- Ohkanda, Junko,Kumasaka, Toshihiko,Takasu, Aki,Hasegawa, Tadashi,Katoh, Akira
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p. 883 - 889
(2007/10/03)
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