20721-17-9

Basic information

• Product Name: 2-HYDROXY-5-METHYLPYRAZINE
• Synonyms: 2-HYDROXY-5-METHYLPYRAZINE;5-METHYLPYRAZIN-2-OL;5-Methyl-2(1H)-pyrazinone;5-Methyl-1H-pyrazin-2-one;5-Methylpyrazin-2(1H)-one;Pyrazinol, 5-methyl-;2,3,4,5-Tetrahydro-7,8-dinitro-3-(trifluoroacetyl)-1,5-methano-1H-4-benzazepine
• CAS NO: 20721-17-9
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11394
• Mol File: 20721-17-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 68-69 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 376.2 °C at 760 mmHg
• Flash Point: 181.3 °C
• Appearance: /
• Density: 1.22 g/cm³
• Vapor Pressure: 3.41E-06mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: 2-8°C
• PKA: 11.72±0.40(Predicted)
• CAS DataBase Reference: 2-HYDROXY-5-METHYLPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-5-METHYLPYRAZINE(20721-17-9)
• EPA Substance Registry System: 2-HYDROXY-5-METHYLPYRAZINE(20721-17-9)

Safety Data

• Hazardous Substances Data: 20721-17-9(Hazardous Substances Data)

Usage

Uses

5-Methyl-2(1H)-pyrazinone is a useful synthetic intermediate. it is a derivative of 2-Hydroxypyrazine (H952710) which is used in the synthesis of potential antioxidants. 2-Hydroxypyrazine (H952710) is also used in the preparation of antibacterial agents as 2-substituted pyrazine derivatives.

InChI:InChI=1/C5H6N2O/c1-4-2-7-5(8)3-6-4/h2-3H,1H3,(H,7,8)

Upstream product

• 1668-10-6 glycinamide hydrochloride 
• 78-98-8 2-oxopropanal 
• 131543-46-9 Glyoxal 
• 33208-99-0 (S)-alaninamide hydrochloride 

Downstream Products

• 5521-58-4 5-methylpyrazin-2-amine 
• 86731-82-0 5-methyl-3-phenyl-1H-pyrazin-2-one 
• 108977-86-2 5-methyl-3,6-diphenyl-1H-pyrazin-2-one 

Relevant articles and documents

Emimycin and its nucleoside derivatives: Synthesis and antiviral activity

The synthesis of emimycin, 5-substituted emimycin analogues and the corresponding ribo- and 2′-deoxyribonucleoside derivatives is described. Emimycin, its 5-substituted congeners and the ribonucleoside derivatives are completely devoid of antiviral activity against RNA viruses. In contrast, some of the 2′-deoxyribosyl emimycin derivatives are potent inhibitors of the replication of herpes simplex virus-1 and varicella-zoster virus, lacking cytotoxicity.

BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.