- Synthesis and antibacterial activity of di-heteryl substitued [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazoles
-
A new series of 3-(5-methyl-1-phenyl-1H-4-pyrazolyl)-6-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl)[1,2,4]triazolo [3,4-b][1,3,4]thiadiazoles 12a-j have been prepared and assayed for their antibacterial activity against human pathogenic Gram-positive bacteria viz., Staphylococcus aureus, Bacillus subtilis and Gram-negative Escherichia coli. Among the screened compounds 12b, 12c and 12f, in which phenyl ring of triazole moiety bear 4-chloro, 4-nitro and 4-fluoro substituents respectively, showed high activity against all the micro-organisms employed. The activities of these compounds are almost equal to the standards.
- Sanjeeva Reddy,Vani Devi,Sunitha,Kalyani,Nagaraj
-
p. 590 - 597
(2017/01/18)
-
- N-ARYLTRIAZOLE COMPOUNDS AS LPAR ANTAGONISTS
-
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, pulmonary fibrosis
- -
-
-
- The synthesis of some new (S)-1-aryl-N-(1-hydroxy-3-phenylpropan-2-yl)-5- methyl-1H-1,2,3-triazole-4-carboxamide
-
Some new (S)-1-aryl-N-(1-hydroxy-3-phenylpropan-2-yl)-5-methyl-1 H-1,2,3-triazole-4-carboxamides 4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j have been synthesized and established by 1H and 13C NMR, IR, MS spectra, CHN analyses, and x-ray
- Shen,Chen,Wu,Dong
-
p. 781 - 786
(2013/08/23)
-
- Synthesis and characterization of some new 1,2,4-triazines containing 1,2,3-triazole
-
A series of 3-(1 -aryl-1 H-1,2,3-triazol-4-yl)-6-phenyl-1,2,4-triazines were synthesized by the reaction of 1-aryl-1tf-1,2,3-triazole-4-carbohydrazide with 2-bromo-1- phenylethanone and sodium acetate in refluxed EtOH and AcOH. Their structures were chara
- Wang, Yan-Fei,Dong, Hong-Ru,Li, Rong-Shan,Dong, Heng-Shan
-
-
- The crystal structures of some 1-aryl-5-methyl-1,2,3-triazole derivatives
-
The two 1-aryl-5-methyl-1,2,3-triazole derivatives were prepared by the 1-aryl-5-methyl-1,2,3-triazol-4-carboxylic acids 3. The yielded products 4a-b were confirmed by NMR, MS, IR spectra. We investigated the crystalline structure of compounds 4a and 4b.
- Dong, Heng-Shan,Dong, Hong-Ru,Zhang, Tong-Qiang
-
experimental part
p. 32 - 35
(2009/06/06)
-
- Synthesis of some novel 3,6-bis(1,2,3-triazolyl)-s-triazolo[3,4-b]-1,3,4- thiadiazole derivatives
-
The cyclization of 1-amino-2-mercapto-5-[1-(4-ethoxyphenyl)-5-methyl-1,2,3- triazol-4-yl]-1,3,4-triazole which was synthesized from p-ethoxyaniline with various triazole acid in absolute phosphorus oxychloride yields 3,6-bis(1,2,3-triazolyl)-s-triazolo[3,
- Dong, Heng-Shan,Wang, Bin
-
p. 103 - 108
(2007/10/03)
-
- Studies on condensed heterocyclic compounds: Part XVIII-synthesis of 6- (1-aryl-5-methyl-1, 2, 3-triazol-4-yl)-3-(4-pyridyl)-s-triazolo[3,4-b]-1. 3, 4-thiadiazoles
-
Several new 6-(1-aryl-5-methyl-1, 2, 3-triazol-4-yl)-3-(4-pyridyl)-s- triazolo[3,4-b]-1, 3, 4-thiadiazoles 3a-j have been synthesized by the condensation of 4-amino-5-mercapto-3-(4-pyridyl)-1, 2, 4-triazole2 with 1- aryl-4-carboxy-5-methyl-1, 2, 3-triazoles 1a-j in the presence of phosphorus oxychloride. The structures of the products obtained are characterized by elemental analyses and spectral data and the fragmentation pattern of the mass spectra of 3a-j is discussed. 3a-j have been screened for their antibacterial activity against B. subtilis and E. coli.
- Sun, Xiao-Wen,Zhang, Yan,Zhang, Zi-Yi,Wang, Qin,Wang, Shu-Fang
-
p. 380 - 383
(2007/10/03)
-
- 1H and 13C NMR - Spectroscopy of substituted 1,2,3-triazoles
-
1-Aryl-4-carboxy-5-methyl-1,2,3-triazoles were prepared by the condensation of aryl azides with ethyl acetoacetate. The structures of these compounds were characterized by MS, IR and 1H and 13C NMR spectroscopy. The measured and calc
- Sun, Xiao-Wen,Xu, Peng-Fei,Zhang, Zi-Yi
-
p. 459 - 460
(2007/10/03)
-