20725-34-2

Usage

Uses

Used in Organic Synthesis:
1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid is used as a building block in organic synthesis for the creation of more complex molecules. Its versatile structure allows for further functionalization and incorporation into a wide range of chemical entities.
Used in Chemical Research:
In the field of chemical research, 1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid serves as a valuable compound for studying reaction mechanisms, exploring new synthetic pathways, and understanding the properties of related triazole-containing compounds.
Used in Pharmaceutical Industry:
1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid is used as a potential pharmaceutical intermediate for the development of new drugs. Its unique structure may offer novel therapeutic opportunities, particularly in the areas of antimicrobial, anticancer, and anti-inflammatory agents.
Used in Agrochemical Industry:
In agrochemicals, 1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid may be utilized as a precursor for the synthesis of bioactive molecules with potential applications in crop protection, such as fungicides, insecticides, and herbicides.
Synthesis:
1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid can be synthesized through various methods, including the Huisgen 1,3-dipolar cycloaddition reaction, which is a powerful tool for the formation of 1,2,3-triazoles from azides and alkynes. This synthetic approach allows for the efficient preparation of 1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid and its derivatives, facilitating further exploration of its properties and applications.

Upstream product

• 2101-88-4 1-azido-4-bromobenzene 
• 141-97-9 ethyl acetoacetate 
• 1147190-28-0 1-(4-bromo-phenyl)-5-methyl-1H-[1,2,3]triazole-4-carboxylic acid methyl ester 
• 5467-74-3 4-Bromophenylboronic acid 
• 361990-21-8 ethyl 1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylate 

Downstream Products

• 20177-64-4 1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazole 
• 361990-21-8 ethyl 1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylate 
• 337980-37-7 C₁₀H₇BrClN₃O 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of di-heteryl substitued [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazoles

A new series of 3-(5-methyl-1-phenyl-1H-4-pyrazolyl)-6-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl)[1,2,4]triazolo [3,4-b][1,3,4]thiadiazoles 12a-j have been prepared and assayed for their antibacterial activity against human pathogenic Gram-positive bacteria viz., Staphylococcus aureus, Bacillus subtilis and Gram-negative Escherichia coli. Among the screened compounds 12b, 12c and 12f, in which phenyl ring of triazole moiety bear 4-chloro, 4-nitro and 4-fluoro substituents respectively, showed high activity against all the micro-organisms employed. The activities of these compounds are almost equal to the standards.

N-ARYLTRIAZOLE COMPOUNDS AS LPAR ANTAGONISTS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, pulmonary fibrosis

The synthesis of some new (S)-1-aryl-N-(1-hydroxy-3-phenylpropan-2-yl)-5- methyl-1H-1,2,3-triazole-4-carboxamide

Some new (S)-1-aryl-N-(1-hydroxy-3-phenylpropan-2-yl)-5-methyl-1 H-1,2,3-triazole-4-carboxamides 4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j have been synthesized and established by 1H and 13C NMR, IR, MS spectra, CHN analyses, and x-ray

Synthesis and characterization of some new 1,2,4-triazines containing 1,2,3-triazole

A series of 3-(1 -aryl-1 H-1,2,3-triazol-4-yl)-6-phenyl-1,2,4-triazines were synthesized by the reaction of 1-aryl-1tf-1,2,3-triazole-4-carbohydrazide with 2-bromo-1- phenylethanone and sodium acetate in refluxed EtOH and AcOH. Their structures were chara

The crystal structures of some 1-aryl-5-methyl-1,2,3-triazole derivatives

The two 1-aryl-5-methyl-1,2,3-triazole derivatives were prepared by the 1-aryl-5-methyl-1,2,3-triazol-4-carboxylic acids 3. The yielded products 4a-b were confirmed by NMR, MS, IR spectra. We investigated the crystalline structure of compounds 4a and 4b.

Synthesis of some novel 3,6-bis(1,2,3-triazolyl)-s-triazolo[3,4-b]-1,3,4- thiadiazole derivatives

The cyclization of 1-amino-2-mercapto-5-[1-(4-ethoxyphenyl)-5-methyl-1,2,3- triazol-4-yl]-1,3,4-triazole which was synthesized from p-ethoxyaniline with various triazole acid in absolute phosphorus oxychloride yields 3,6-bis(1,2,3-triazolyl)-s-triazolo[3,

Studies on condensed heterocyclic compounds: Part XVIII-synthesis of 6- (1-aryl-5-methyl-1, 2, 3-triazol-4-yl)-3-(4-pyridyl)-s-triazolo[3,4-b]-1. 3, 4-thiadiazoles

Several new 6-(1-aryl-5-methyl-1, 2, 3-triazol-4-yl)-3-(4-pyridyl)-s- triazolo[3,4-b]-1, 3, 4-thiadiazoles 3a-j have been synthesized by the condensation of 4-amino-5-mercapto-3-(4-pyridyl)-1, 2, 4-triazole2 with 1- aryl-4-carboxy-5-methyl-1, 2, 3-triazoles 1a-j in the presence of phosphorus oxychloride. The structures of the products obtained are characterized by elemental analyses and spectral data and the fragmentation pattern of the mass spectra of 3a-j is discussed. 3a-j have been screened for their antibacterial activity against B. subtilis and E. coli.

1H and 13C NMR - Spectroscopy of substituted 1,2,3-triazoles

1-Aryl-4-carboxy-5-methyl-1,2,3-triazoles were prepared by the condensation of aryl azides with ethyl acetoacetate. The structures of these compounds were characterized by MS, IR and 1H and 13C NMR spectroscopy. The measured and calc