207307-51-5

Basic information

• Product Name: Boronic Acid, [1-(Triphenylmethyl)-1H-Pyrazol-4-YL
• Synonyms: Boronic Acid, [1-(Triphenylmethyl)-1H-Pyrazol-4-YL;(1-Trityl-1H-pyrazol-4-yl)boronic acid
• CAS NO: 207307-51-5
• Molecular Formula: C₂₂H₁₉BN₂O₂
• Molecular Weight: 354.20946
• Mol File: 207307-51-5.mol

Chemical Properties

• Melting Point: 85-87 °C
• Boiling Point: 585.7±60.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.46±0.10(Predicted)
• CAS DataBase Reference: Boronic Acid, [1-(Triphenylmethyl)-1H-Pyrazol-4-YL(CAS DataBase Reference)
• NIST Chemistry Reference: Boronic Acid, [1-(Triphenylmethyl)-1H-Pyrazol-4-YL(207307-51-5)
• EPA Substance Registry System: Boronic Acid, [1-(Triphenylmethyl)-1H-Pyrazol-4-YL(207307-51-5)

Safety Data

• Hazardous Substances Data: 207307-51-5(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
Boronic Acid, [1-(Triphenylmethyl)-1H-Pyrazol-4-YL] is used as a building block for the development of new drugs and pharmaceuticals due to its unique structure and potential to form reversible covalent bonds with diols.
Used in Organic Synthesis:
Boronic Acid, [1-(Triphenylmethyl)-1H-Pyrazol-4-YL is utilized as an intermediate in organic synthesis, allowing for the creation of complex molecules and contributing to the advancement of chemical research.
Used in Enzyme and Receptor Inhibition:
Boronic Acid, [1-(Triphenylmethyl)-1H-Pyrazol-4-YL] is used as an inhibitor for enzymes and receptors, taking advantage of its ability to form reversible covalent bonds with diols, which can be crucial in the development of treatments for various diseases and conditions.
Further research and testing of Boronic Acid, [1-(Triphenylmethyl)-1H-Pyrazol-4-YL] could reveal its full potential and possible applications in the field of medicinal chemistry, potentially leading to breakthroughs in drug development and treatment of a wide range of diseases.

Upstream product

• 95162-14-4 4-bromo-1-trityl-1H-pyrazole 

Downstream Products

• 474709-53-0 6-(1-trityl-1H-4-pyrazolyl)imidazo[1,2-a]pyridine 
• 757978-28-2 1-benzenesulfonyl-5-morpholin-4-yl-3-(trityl-1H-pyrazol-4-yl)-pyrrolo[2,3-B]pyridine 
• 757978-20-4 1-Benzenesulfonyl-5-bromo-3-(1-trityl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine 
• 923583-58-8 1-Benzenesulfonyl-5-phenylsulfanyl-3-(1-trityl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine 
• 207307-84-4 6,6-Dimethyl-3-methylthio-1-((1-triphenylmethyl)pyrazol-4-yl)-4,5,6,7-tetrahydrobenzo[c]thiophen-4-one 

Relevant articles and documents

Synthesis of 4-aryl-1H-pyrazoles by Suzuki-Miyaura cross coupling reaction between 4-bromo-1H-1-trityl-pyrazole and arylboronic acids

A general procedure for the synthesis of 4-aryl-1H-pyrazoles by the Suzuki-Miyaura cross coupling reaction between 4-bromo-1H-1-tritylpyrazole and commercially available arylboronic acids was developed. Using this procedure, a direct synthesis of 4-aryl-1H-pyrazoles possessing functional groups, such as hydroxyl, nitro, and amino groups, on the aryl ring was realized. Those molecules could not be prepared by our previous synthesis of 4-aryl-1H-pyrazoles via the Kumada cross coupling reaction.