207405-64-9

Basic information

• Product Name: tert-Butyl 5-(benzylaMino)-2-aza-bicyclo[2.2.1]heptane-2-carboxylate
• Synonyms: tert-Butyl 5-(benzylaMino)-2-aza-bicyclo[2.2.1]heptane-2-carboxylate;(1R,4R,5R)-rel-5-[(Phenylmethyl)amino]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester;tert-butyl 5-(benzylaMino)-2-aza-bicyclo[2.2.1]heptane-2-carbo×ylate;(1R,4R,5R)-rel-tert-Butyl 5-(benzylamino)-2-azabicyclo[2.2.1]heptane-2-carboxylate
• CAS NO: 207405-64-9
• Molecular Formula: C18H26N2O2
• Molecular Weight: 302.41124
• Mol File: 207405-64-9.mol

Chemical Properties

• Appearance: /
• Density: 1.12
• Storage Temp.: 2-8°C
• CAS DataBase Reference: tert-Butyl 5-(benzylaMino)-2-aza-bicyclo[2.2.1]heptane-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 5-(benzylaMino)-2-aza-bicyclo[2.2.1]heptane-2-carboxylate(207405-64-9)
• EPA Substance Registry System: tert-Butyl 5-(benzylaMino)-2-aza-bicyclo[2.2.1]heptane-2-carboxylate(207405-64-9)

Safety Data

• Hazardous Substances Data: 207405-64-9(Hazardous Substances Data)

Usage

Uses

Used in Chemical Research:
Tert-Butyl 5-(benzylamino)-2-aza-bicyclo[2.2.1]heptane-2-carboxylate is utilized as a research compound for studying its synthesis and properties. Its complex structure and potential reactivity make it a valuable tool for understanding various chemical reactions and mechanisms.
Used in Pharmaceutical Development:
In the pharmaceutical industry, tert-Butyl 5-(benzylamino)-2-aza-bicyclo[2.2.1]heptane-2-carboxylate is employed as a lead compound for drug design and synthesis. Its unique structure and potential biological activity suggest that it may serve as a starting point for the development of new therapeutic agents.
Used in Drug Design:
Tert-Butyl 5-(benzylamino)-2-aza-bicyclo[2.2.1]heptane-2-carboxylate is used as a structural motif in drug design. Its incorporation into drug candidates can potentially enhance their pharmacological properties, such as selectivity, potency, and bioavailability.
Used in Synthesis of Bioactive Compounds:
tert-Butyl 5-(benzylaMino)-2-aza-bicyclo[2.2.1]heptane-2-carboxylate is also used as a synthetic intermediate for the preparation of bioactive molecules. Its versatile structure allows for the introduction of various functional groups, enabling the synthesis of a wide range of biologically relevant compounds.

Upstream product

• 1400808-00-5 5-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 100-46-9 benzylamine 
• 198835-06-2 5-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 198835-06-2 tert-butyl 5-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 702666-73-7 tert-butyl (1R,4S)-(+)-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate 
• 207405-69-4 (1R,4R,5S)-tert-butyl 5-hydroxy-2-azabicyclo[2.2.1]heptanes-2-carboxylate 
• 79200-56-9 (-)-2-azabicyclo[2.2.1]hept-5-en-3-one 
• 542-92-7 cyclopenta-1,3-diene 
• 198835-03-9 rac-tert-butyl (1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1290539-90-0 tert-butyl (1R,4R,5R)-5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 1290539-90-0 endo-5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 1290539-90-0 5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

NOVEL QUINOLINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE

The present invention relates to compounds of formula (I), (I), wherein R1, R2 and R3 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

NITROGEN HETEROCYCLIC COMPOUNDS AND METHODS OF USE

The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparing the compounds, compositions comprising the compounds, and methods of using the compounds as inhibitors of receptor tyrosine kinases, in particular oncogenic mutants of ErbB-receptors e.g. in the treatment of cancer.

Nitrogen-containing heterocyclic derivative and preparation thereof

The invention discloses a nitrogen-containing heterocyclic compound as shown in a formula (I), a stereoisomer, a solvate, a metabolite, a pharmaceutically acceptable salt, a co-crystal or a prodrug of the nitrogen-containing heterocyclic compound, a pharmaceutical composition of the nitrogen-containing heterocyclic compound, a preparation method of the nitrogen-containing heterocyclic compound, and an application of the nitrogen-containing heterocyclic compound in prevention and treatment of autotaxin mediated diseases.

Synthesis and biological evaluation of pyrimidine derivatives with diverse azabicyclic ether/amine as novel GPR119 agonist

A class of novel pyrimidine derivatives bearing diverse conformationally restricted azabicyclic ether/amine were designed, synthesized and evaluated for their GPR119 agonist activities against type 2 diabetes. Most compounds exhibited superior hEC50

TRICYCLIC GYRASE INHIBITORS FOR USE AS ANTIBACTERIAL AGENTS

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

TRICYCLIC GYRASE INHIBITORS

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS

The invention relates to compounds of formula (I) wherein Z, Rc, y, m, u, Ar2, n, X, Rc', l and Ar2 are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.