198835-06-2

Usage

Uses

Used in Pharmaceutical Industry:
TERT-BUTYL 5-OXO-2-AZABICYCLO[2.2.1]HEPTANE-2-CARBOXYLATE is used as a building block for the synthesis of various pharmaceuticals due to its unique structure and properties that can be leveraged in drug design and development.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, TERT-BUTYL 5-OXO-2-AZABICYCLO[2.2.1]HEPTANE-2-CARBOXYLATE serves as a key component in the creation of agrochemicals, contributing to the development of effective and novel products for agricultural applications.
Used in Scientific Research:
TERT-BUTYL 5-OXO-2-AZABICYCLO[2.2.1]HEPTANE-2-CARBOXYLATE is also used as a subject of study in scientific research for its potential pharmacological activities, with the aim of uncovering new applications and enhancing understanding of its properties and interactions.

InChI:InChI=1S/C11H17NO3/c1-11(2,3)15-10(14)12-6-7-4-8(12)5-9(7)13/h7-8H,4-6H2,1-3H3

Upstream product

• 79-37-8 oxalyl dichloride 
• 207405-60-5 (1R,4R)-1,1-Dimethylethyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 188345-71-3 2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]hept-5-ene 
• 198835-03-9 rac-tert-butyl (1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 542-92-7 cyclopenta-1,3-diene 
• 79200-56-9 (-)-2-azabicyclo[2.2.1]hept-5-en-3-one 
• 207405-69-4 (1R,4R,5S)-tert-butyl 5-hydroxy-2-azabicyclo[2.2.1]heptanes-2-carboxylate 
• 702666-73-7 tert-butyl (1R,4S)-(+)-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate 
• 1932042-59-5 C₁₁H₁₉NO₃ 

Downstream Products

• 1290539-90-0 5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 207405-61-6 5-oximino-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 1290539-90-0 endo-5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 1290539-90-0 exo-5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 198835-03-9 tert-butyl (1RS,4RS,5RS)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 1290539-90-0 tert-butyl (1R,4R,5R)-5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 207405-64-9 tert-butyl (1R,4R)-5-(benzylamino)-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 198835-03-9 (1R,4R,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis and biological evaluation of pyrimidine derivatives with diverse azabicyclic ether/amine as novel GPR119 agonist

A class of novel pyrimidine derivatives bearing diverse conformationally restricted azabicyclic ether/amine were designed, synthesized and evaluated for their GPR119 agonist activities against type 2 diabetes. Most compounds exhibited superior hEC50

TRICYCLIC GYRASE INHIBITORS FOR USE AS ANTIBACTERIAL AGENTS

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

Synthesis of novel azanorbornylpurine derivatives

Azanorbornylpurine derivatives were prepared by Mitsunobu reaction of appropriate hydroxyazanorbornane derivative with 6-chloropurine or construction of purine base at azanorbornylamines. The prepared target compounds were evaluated for antiviral activity and effect on neuronal and muscle nicotinic acetylcholine receptors.

TRICYCLIC GYRASE INHIBITORS

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

BRIDGED BICYCLIC RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE

The present invention is directed to synthetic bridged bicyclic compounds that are inhibitors of rho-associated protein kinase. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptab

Improved synthesis of monoprotected 5- and 6-amino-2-azanorbornanes

(Chemical Equation Presented) An improved synthesis of Boc-monoprotected 5- and 6-amino-2-azanorbornanes is reported. The synthetic scheme consists of five steps and allows multigram quantities of the title compounds to be obtained. The regio- and stereochemistries of the products are established by two-dimensional NMR experiments. Copyright Taylor & Francis Group, LLC.

PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS

The invention relates to compounds of formula (I) wherein Z, Rc, y, m, u, Ar2, n, X, Rc', l and Ar2 are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

Heterocyclic compounds

The present invention provides heterocyclic 2-aza-bicyclo[2.2.1]heptane compounds which are useful for modulating a muscarinic ptor.