207462-72-4

Basic information

• Product Name: 3-(3,5-DIFLUORO-PHENYL)-PROPIONALDEHYDE
• Synonyms: 3-(3,5-DIFLUORO-PHENYL)-PROPIONALDEHYDE
• CAS NO: 207462-72-4
• Molecular Formula: C₉H₈F₂O
• Molecular Weight: 170.1560264
• Mol File: 207462-72-4.mol

Chemical Properties

• Boiling Point: 193.446°C at 760 mmHg
• Flash Point: 71.461°C
• Appearance: /
• Density: 1.178g/cm³
• Vapor Pressure: 0.464mmHg at 25°C
• Refractive Index: 1.474
• CAS DataBase Reference: 3-(3,5-DIFLUORO-PHENYL)-PROPIONALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,5-DIFLUORO-PHENYL)-PROPIONALDEHYDE(207462-72-4)
• EPA Substance Registry System: 3-(3,5-DIFLUORO-PHENYL)-PROPIONALDEHYDE(207462-72-4)

Safety Data

• Hazardous Substances Data: 207462-72-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H8F2O/c10-8-4-7(2-1-3-12)5-9(11)6-8/h3-6H,1-2H2

Upstream product

• 2265-91-0 1,3-difluoro-5-iodobenzene 
• 107-18-6 allyl alcohol 
• 163978-51-6 ethyl 3-(3,5-difluorophenyl)propionate 
• 289677-10-7 (R)-3-(3-cyclopentyl-1-oxopropyl)-4-(phenylmethyl)-2-oxazolidinone 
• 330841-07-1 3-(2 (R)-cyclopentylmethyl-3(S)-hydroxyl-5-phenyl-1-oxopentyl)-4(R)-(phenylmethyl)-2-oxazolidinone 
• 84315-23-1 (trans)-3-(3,5-difluorophenyl)acrylic acid 
• 84315-24-2 3-(3,5-difluorophenyl)propionic acid 
• 461-96-1 3,5-difluorobromobenzene 

Downstream Products

• 926247-32-7 5-(3,5-difluorobenzyl)thiazol-2-amine 

Relevant articles and documents

Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide

A series of structurally novel stearoyl-CoA desaturase-1 (SCD-1) inhibitors has been identified by optimizing a hit from our corporate library. Preliminary structure-activity relationship (SAR) studies led to the discovery of the highly potent and orally bioavailable thiazole-based SCD-1 inhibitor, 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide (23a).

Norstatines from Aldehydes by sequential organocatalytic α-amination and passerini reaction

The combination of the enantioselective, organocatalytic α-amination of aldehydes by diazodicarboxylates and the Passerini reaction provides rapid access to norstatine-based peptidomimetics. These intermediates were elaborated further by deprotection and cleavage of the N-N bond to provide useful building blocks for aspartic protease inhibitors. Coupling of the compounds 76-86 with the mono-isophthalamide 91 provided moderate inhibitors of human β-secretase (BACE) 92-102. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production

This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A

Hydroxyalkanoylaminolactams and related structures as inhibitors of A-beta protein production

This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A

Hydroxyalkanoylaminolactams and related structures as inhibitors of a beta protein production

This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A

Dioxane derivatives, liquid-crystal compositions containing the same, and liquid-crystal display devices made by using the same

The present invention provides liquid crystalline compounds having a high voltage holding ratio and a remarkably high Δε value, electric and chemical stability, and having good compatibility with known liquid crystalline compounds, liquid crystal compositions containing the compound, and liquid crystal display devices constituted by using the compounds. The liquid crystalline compounds of the present invention are particular dioxane derivatives represented by general formula (1). Further, the present invention relates to liquid crystal compositions characterized in that the compositions comprise at least one of the derivatives, and liquid crystal display devices constituted by using the compositions.